Discovery and Applied Research for Technological Innovations to Improve Human Health

A federal assistance program listed on Grants.gov by National Institutes of Health (Department of Health and Human Services). The listing number stays the same from one funding round to the next, so this page is the one to watch between announcements.

Funding history

Open opportunities under this listing

• HEAL Initiative: Whole Joint Health Program (R61/R33 Clinical Trial Required)
  Open PAR-27-045 · closes October 30, 2026
• NIH Research Software Engineer (RSE) Award (R50 Clinical Trials Not Allowed)
  Open RFA-OD-24-011 · closes December 4, 2026
• Intervention Research to Improve Native American Health (R01 Clinical Trial Optional)
  Open PAR-25-379 · closes January 7, 2027
• BRAIN Initiative: Preclinical Proof of Concept for Novel Recording and Modulation Technologies in the Human CNS (R18 - Clinical Trial Not Allowed)
  Open RFA-NS-24-031 · closes January 28, 2027
• BRAIN Initiative: Development and Validation of Novel Tools to Probe Cell-Specific and Circuit-Specific Processes in the Brain (R01 Clinical Trial Not Allowed)
  Open RFA-MH-26-170 · closes February 8, 2027
• BRAIN Initiative: Exploratory Research Opportunities Using Invasive Neural Recording and Stimulating Technologies in the Human Brain (R61 Clinical Trial Not Allowed)
  Open RFA-DC-27-004 · closes February 11, 2027
• NIH, CDC and FDA Small Business Innovation Research Grant (Parent SBIR [R43/R44] Clinical Trial Optional)
  Open PA-27-100 · closes April 5, 2027
• NIH Small Business Technology Transfer Grant (Parent STTR [R41/R42] Clinical Trial Optional)
  Open PA-27-102 · closes April 5, 2027
• Mentored Research Scientist Development Award (Parent K01 - Independent Clinical Trial Required)
  Open PA-24-175 · closes May 7, 2027
• Mentored Research Scientist Development Award (Parent K01 - Independent Clinical Trial Not Allowed)
  Open PA-24-176 · closes May 7, 2027
• Mentored Patient-Oriented Research Career Development Award (Parent K23 Independent Clinical Trial Not Allowed)
  Open PA-24-185 · closes May 7, 2027
• Mentored Quantitative Research Development Award (Parent K25 Independent Clinical Trial Required)
  Open PA-24-190 · closes May 7, 2027
• Mentored Quantitative Research Development Award (Parent K25 Independent Clinical Trial Not Allowed)
  Open PA-24-191 · closes May 7, 2027
• NIH Pathway to Independence Award (Parent K99/R00 Independent Clinical Trial Required)
  Open PA-24-193 · closes May 7, 2027
• NIH Pathway to Independence Award (Parent K99/R00 Independent Clinical Trial Not Allowed)
  Open PA-24-194 · closes May 7, 2027
• New Approaches for Measuring Brain Changes Across Longer Timespans (R01 Clinical Trial Optional)
  Open PAR-25-279 · closes May 7, 2027
• Mentored Clinical Scientist Research Career Development Award (Parent K08 Independent Clinical Trial Required)
  Open PA-24-181 · closes May 8, 2027
• Mentored Clinical Scientist Research Career Development Award (Parent K08 Independent Clinical Trial Not Allowed)
  Open PA-24-182 · closes May 8, 2027
• Mentored Patient-Oriented Research Career Development Award (Parent K23 Independent Clinical Trial Required)
  Open PA-24-184 · closes May 8, 2027
• BRAIN Initiative: Reagent Resources for Brain Cell Type-Specific Access to Broaden Distribution of Enabling Technologies for Neuroscience (U24 Clinical Trial Not Allowed)
  Open RFA-MH-26-120 · closes June 15, 2027
• BRAIN Initiative: Brain Behavior Quantification and Synchronization- Next Generation Sensor Technology Development (U01 Clinical Trial Optional)
  Open RFA-MH-26-140 · closes June 15, 2027
• Change of Recipient Organization (Type 7 Parent Clinical Trial Optional)
  Open PA-24-254 · closes July 12, 2027
• Successor-in-Interest (Type 6 Parent Clinical Trial Optional)
  Open PA-24-253 · closes July 17, 2027
• NIH Support for Conferences and Scientific Meetings (Parent R13 Clinical Trial Not Allowed)
  Open PA-25-080 · closes September 7, 2027
• Bioengineering Partnerships with Industry (U01 Clinical Trial Optional)
  Open PAR-24-325 · closes September 7, 2027
• BRAIN Initiative Connectivity across Scales (BRAIN CONNECTS): Specialized Projects for Scalable Technologies (U01 Clinical Trial Not Allowed)
  Open RFA-NS-27-015 · closes October 4, 2027
• BRAIN Initiative: Theories, Models and Methods for Analysis of Complex Data from the Brain (R01 Clinical Trial Not Allowed)
  Open RFA-DA-27-004 · closes November 8, 2027
• NIH Research Project Grant (Parent R01 Clinical Trial Not Allowed)
  Open PA-25-301 · closes January 7, 2028
• NIH Small Research Grant Program (Parent R03 Clinical Trial Not Allowed)
  Open PA-25-302 · closes January 7, 2028
• NIH Exploratory/Developmental Research Project Grant (Parent R21 Clinical Trial Not Allowed)
  Open PA-25-304 · closes January 7, 2028
• NIH Research Project Grant (Parent R01 Clinical Trial Required)
  Open PA-25-305 · closes January 7, 2028
• NIH Exploratory/Developmental Research Project Grant (Parent R21 Clinical Trial Required)
  Open PA-25-306 · closes January 7, 2028
• Academic Research Enhancement Award (AREA) for Undergraduate-Focused Institutions (R15 Clinical Trial Not Allowed)
  Open PAR-25-134 · closes January 7, 2028
• Research Enhancement Award Program (REAP) for Health Professional Schools and Graduate Schools (R15 Clinical Trial Not Allowed)
  Open PAR-25-298 · closes January 7, 2028
• Blueprint MedTech Translator (UG3/UH3 - Clinical Trial Optional)
  Open PAR-25-383 · closes January 28, 2028
• Ruth L. Kirschstein National Research Service Award (NRSA) Institutional Research Training Grant (Parent T32)
  Open PA-25-168 · closes May 4, 2028
• Ruth L. Kirschstein National Research Service Award (NRSA) Short-Term Institutional Research Training Grant (Parent T35)
  Open PA-25-280 · closes May 7, 2028
• Ruth L. Kirschstein National Research Service Award (NRSA) Individual Predoctoral Fellowship (Parent F31)
  Open PA-25-422 · closes May 7, 2028
• Ruth L. Kirschstein National Research Service Award (NRSA) Individual Postdoctoral Fellowship (Parent F32)
  Open PA-25-423 · closes May 7, 2028
• Ruth L. Kirschstein National Research Service Award (NRSA) Individual Fellowship for Students at Institutions Without NIH-Funded Institutional Predoctoral Dual-Degree Training Programs (Parent F30)
  Open PA-25-425 · closes May 7, 2028
• BRAIN Initiative: Integrative Team-Research BRAIN Circuits Program - iBCP (RM1 Clinical Trial Not Allowed)
  Open RFA-NS-27-002 · closes June 23, 2028
• Transformative Non-Invasive/Minimally Invasive Technologies for Imaging the Olfactory System Across Scales (R01 CT Optional)
  Open RFA-DC-27-003 · closes August 21, 2028
• Stephen I. Katz Early Stage Investigator Research Project Grant (R01 Clinical Trial Not Allowed)
  Open PAR-25-322 · closes August 25, 2028
• Support for Research Excellence (SuRE) Award (R16 Clinical Trial Not Allowed)
  Open PAR-25-414 · closes September 7, 2028
• Support for Research Excellence First Independent Research (SuRE-First) Award (R16 - Clinical Trial Not Allowed)
  Open PAR-25-415 · closes September 7, 2028
• Administrative Supplements to Existing NIH Grants and Cooperative Agreements (Parent Admin Supp Clinical Trial Optional)
  Open PA-26-001 · closes November 30, 2028
• Limited Competition: Instrumentation Grant Program for Resource-Limited Institutions (S10 - Clinical Trial Not Allowed)
  Open PAR-27-067 · closes January 26, 2029
• BRAIN Initiative: Research Opportunities Using Invasive Neural Recording and Stimulating Technologies in the Human Brain (R01 Clinical Trial Not Allowed)
  Open RFA-NS-28-010 · closes February 8, 2029
• SBIR/STTR Commercialization Readiness Pilot (CRP) Program (Parent SB1 Clinical Trial Optional)
  Open PAR-27-098 · closes April 5, 2029
• NIH Science Education Partnership Award (SEPA) (R25 - Clinical Trial Not Allowed)
  Open PAR-27-077 · closes May 25, 2029
• Academic Career Excellence (ACE) Award (K32 Independent Clinical Trial Not Allowed)
  Open PAR-27-062 · closes July 12, 2029

Forecasted

• National Centers for Biomedical Imaging and Bioengineering (NCBIB) (P41 Clinical Trials Optional)
  Forecasted PAR-27-105
• NextTech: Translational Development of Next-Generation Diagnostic and Therapeutic Devices (R18 Clinical Trial Not Allowed)
  Forecasted RFA-EB-26-004
• Bioengineering Research, Innovation and Technology Education (BRITE) Program (R25 Clinical Trial Not Allowed)
  Forecasted PAR-26-025
• Biomedical Engineering, Imaging, and Technology Acceleration (BEITA) at Historically Black Colleges and Universities
  Forecasted RFA-EB-26-003
• Forecast to Publish a Notice of Funding Opportunity for Small Business Transition Grant For Early Career Scientists (R41/R42 Clinical Trial Not Allowed)
  Forecasted FOR-CA-25-087
• Notice of Intent to Publish a Funding Opportunity Announcement for Trailblazer Award for New and Early-Stage Investigators (R21 Clinical Trial Optional)
  Forecasted FOR-EB-26-001
• Small Business Translator: MedTech and Digital Health Technologies
  Forecasted FOR-NS-25-017

Recently closed

• Shared Instrumentation Grant (SIG) Program (S10 Clinical Trial Not Allowed)
  Closed PAR-24-265 · closed before June 1, 2027
• High-End Instrumentation (HEI) Grant Program (S10 Clinical Trial Not Allowed)
  Closed PAR-24-264 · closed before June 1, 2027
• BRAIN Initiative: Clinical Studies to Advance Next-Generation Devices for Recording and Modulation in the Human Central Nervous System (UH3 Clinical Trial Optional)
  Closed RFA-NS-25-022 · closed September 28, 2026
• BRAIN Initiative: Next-Generation Devices for Recording and Modulation in the Human Central Nervous System (UG3/UH3 Clinical Trial Optional)
  Closed RFA-NS-25-021 · closed September 28, 2026
• National Centers for Biomedical Imaging and Bioengineering (NCBIB) (P41 Clinical Trials Optional)
  Closed PAR-23-235 · closed September 7, 2026
• HEAL Initiative: Limited Competition for the HEALthy Brain and Child Development (HBCD) Study – Consortium Administrative Core and Data Coordinating Center (U24 Clinical Trial Not Allowed)
  Closed RFA-DA-27-014 · closed July 10, 2026
• HEAL Initiative: Limited Competition for the HEALthy Brain and Child Development Study - Research Project Sites (Collaborative U01- Clinical Trial Not Allowed)
  Closed RFA-DA-27-013 · closed July 10, 2026
• BRAIN Initiative: Production and distribution facilities for brain cell type-specific access reagents (U24 Clinical Trial Not Allowed)
  Archived RFA-MH-25-105 · closed July 1, 2026
• BRAIN Initiative: Data Archives for the BRAIN Initiative (R24 Clinical Trial Optional)
  Archived RFA-MH-25-110 · closed June 24, 2026
• BRAIN Initiative: Promoting Health for All Through BRAIN Technology Partnerships (R34 - Clinical Trials Not Allowed)
  Archived RFA-NS-25-016 · closed June 17, 2026
• BRAIN Initiative: New Technologies and Novel Approaches for Recording and Modulation in the Nervous System (R01 Clinical Trial Not Allowed)
  Archived RFA-NS-25-018 · closed June 16, 2026
• BRAIN Initiative: Optimization of Instrumentation and Device Technologies for Recording and Modulation in the Nervous System (U01 Clinical Trials Not Allowed)
  Archived RFA-NS-25-017 · closed June 16, 2026
• BRAIN Initiative: New Concepts and Early-Stage Research for Recording and Modulation in the Nervous System (R21) (Clinical Trial Not Allowed)
  Archived RFA-EY-25-001 · closed June 15, 2026
• Trailblazer Award for New and Early Stage Investigators (R21 Clinical Trial Optional)
  Archived PA-25-169 · closed May 7, 2026
• Mobile Health: Technology and Outcomes in Low and Middle Income Countries (R21/R33 - Clinical Trial Optional)
  Archived PAR-25-242 · closed March 20, 2026
• Enhancement and Management of Established Biomedical Data Repositories and Knowledgebases (U24 Clinical Trial Not Allowed)
  Archived PAR-23-237 · closed January 25, 2026
• NIH HEAL Initiative PainCare Clinician Training Program (PCTP): Mentored Patient-Oriented Research Career Development award (K23 - Clinical Trial Required)
  Archived PAR-24-220 · closed January 22, 2026
• NIH HEAL Initiative PainCare Clinician Training Program (PCTP): Mentored Clinical Scientist Development Awards (K08 - Clinical Trials Not Allowed)
  Archived PAR-24-219 · closed January 22, 2026
• NIH HEAL Initiative PainCare Clinician Training Program (PCTP): Mentored Clinical Scientist Development Awards (K08 - Clinical Trials Required)
  Archived PAR-24-217 · closed January 22, 2026
• Technologies for Improving Minority Health and Eliminating Health Disparities (R41/R42- Clinical Trial Optional)
  Archived RFA-MD-24-007 · closed November 17, 2025
• Innovations for Healthy Living - Improving Minority Health and Eliminating Health Disparities (R43/R44 - Clinical Trial Optional)
  Archived RFA-MD-24-006 · closed November 17, 2025
• NIH Blueprint for Neuroscience: Coordination Center for Interoception Research (BPCCIR) (U24, Clinical Trial Not Allowed)
  Archived RFA-AT-25-004 · closed November 10, 2025
• Administrative Supplements to Existing NIH Grants and Cooperative Agreements (Parent Admin Supp Clinical Trial Optional)
  Archived PA-20-272 · closed September 29, 2025
• SBIR/STTR Commercialization Readiness Pilot (CRP) Program Technical Assistance and Late Stage Development (SB1, Clinical Trial Not Allowed)
  Archived PAR-23-219 · closed September 5, 2025
• PHS 2024-2 Omnibus Solicitation of the NIH for Small Business Technology Transfer Grant Applications (Parent STTR [R41/R42] Clinical Trial Required)
  Archived PA-24-248 · closed September 5, 2025
• PHS 2024-2 Omnibus Solicitation of the NIH for Small Business Technology Transfer Grant Applications (Parent STTR [R41/R42] Clinical Trial Not Allowed)
  Archived PA-24-247 · closed September 5, 2025
• PHS 2024-2 Omnibus Solicitation of the NIH and CDC for Small Business Innovation Research Grant Applications (Parent SBIR [R43/R44] Clinical Trial Required)
  Archived PA-24-246 · closed September 5, 2025
• PHS 2024-2 Omnibus Solicitation of the NIH, CDC and FDA for Small Business Innovation Research Grant Applications (Parent SBIR [R43/R44] Clinical Trial Not Allowed)
  Archived PA-24-245 · closed September 5, 2025
• Instrumentation Grant Program for Resource-Limited Institutions (S10 - Clinical Trial Not Allowed)
  Archived PAR-23-138 · closed July 3, 2025
• Building Sustainable Software Tools for Open Science (R03 Clinical Trial Not Allowed)
  Archived RFA-OD-24-010 · closed May 23, 2025
• BRAIN Initiative: Research on the Ethical Implications of Advancements in Neurotechnology and Brain Science (R21 Clinical Trial Optional)
  Archived RFA-MH-25-171 · closed May 23, 2025
• BRAIN Initiative: Research on the Ethical Implications of Advancements in Neurotechnology and Brain Science (R01 Clinical Trial Optional)
  Archived RFA-MH-25-170 · closed May 23, 2025
• BRAIN Initiative: Exploratory Research Opportunities Using Invasive Neural Recording and Stimulating Technologies in the Human Brain (R61 Basic Experimental Studies with Humans Required)
  Archived RFA-DC-24-001 · closed May 23, 2025
• BRAIN Initiative: Brain-Behavior Quantification and Synchronization Transformative and Integrative Models of Behavior at the Organismal Level (U01 Clinical Trials Not Allowed)
  Archived RFA-DA-24-041 · closed May 23, 2025
• BRAIN Initiative: Brain-Behavior Quantification and Synchronization Transformative and Integrative Models of Behavior at the Organismal Level (U01 Clinical Trial Optional)
  Archived RFA-DA-24-040 · closed May 23, 2025
• Support for Research Excellence (SuRE) Award (R16 Clinical Trial Not Allowed)
  Archived PAR-24-144 · closed May 23, 2025
• Stephen I. Katz Early Stage Investigator Research Project Grant (R01 Clinical Trial Not Allowed)
  Archived PAR-24-075 · closed May 23, 2025
• Ruth L. Kirschstein National Research Service Award (NRSA) Individual Predoctoral Fellowship (Parent F31)
  Archived PA-23-272 · closed May 7, 2025
• Ruth L. Kirschstein National Research Service Award (NRSA) Individual Postdoctoral Fellowship (Parent F32)
  Archived PA-23-262 · closed May 7, 2025
• Ruth L. Kirschstein National Research Service Award (NRSA) Individual Fellowship for Students at Institutions Without NIH-Funded Institutional Predoctoral Dual-Degree Training Programs (Parent F30)
  Archived PA-23-261 · closed May 7, 2025