HEAL Initiative: Whole Joint Health Program (R61/R33 Clinical Trial Required)
Apply on Grants.gov →Application closes October 30, 2026
- Posted
- September 28, 2026
- Closes
- October 30, 2026
- Cost sharing
- No
- Instrument
- Grant
- Assistance listing
- 93.473, 93.273, 93.866, 93.846, 93.853, 93.121, 93.213, 93.286
- Category
- Health
- Archives
- December 29, 2026
Program funding history
Awards made under Assistance Listing 93.273 (one of 8 on this opportunity) across FY2025–FY2027, from public federal spending records.
- FY2025 obligated
- $449M
- FY2026 obligated
- $461.5M
- FY2027 (to date) obligated
- $0
- Awards in window
- 2,078
Top recipients: Yale Univ, Trustees of Indiana University, University of North Carolina at Chapel Hill, University of California, San Diego, University of Washington
Source: USAspending.gov · refreshed October 2026 · Program page: awards, recipients and the opportunities under this listing →
Synopsis
The NIH Helping to End Addiction Long-term® (HEAL) Initiative is releasing this Notice of Funding Opportunity (NOFO) to support a phased mechanistic clinical research program focusing on understudied biological mechanisms that drive joint pain. The phased projects supported by this program (of up to five years total in duration) will first identify and validate multi-tissue mechanisms underlying joint pain, then test non-pharmacologic or multimodal interventions that directly target these mechanisms. The initiative responds to priorities identified in the 2023 HEAL Whole Joint Pain Workshop and supports the broader goals of the NIH HEAL Initiative and the Make America Healthy Again vision by advancing safe, non-addictive, and prevention-oriented approaches to chronic pain.
Who can apply
- Private institutions of higher education
- Independent school districts
- State governments
- City or township governments
- Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education
- Public and State controlled institutions of higher education
- Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education
- County governments
- For profit organizations other than small businesses
- Small businesses
- Special district governments
- Public housing authorities/Indian housing authorities
- Native American tribal governments (Federally recognized)
- Native American tribal organizations (other than Federally recognized tribal governments)
- Others (see text field entitled "Additional Information on Eligibility" for clarification)
Refer to Section III. Eligibility Information in the NOFO for additional information on eligibility. Foreign Organizations/International CollaborationsNon-domestic (non-U.S.) Entities (Foreign Organizations) are not eligible to apply. Non-domestic (non-U.S.) components of U.S. Organizations are not eligible to apply. Foreign components, as defined in the NIH Grants Policy Statement, are not allowed.
How to apply
Applications go through the official government listing. Grants Radar links you straight to the source — applying is free.
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