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NIH Exploratory/Developmental Research Project Grant (Parent R21 Clinical Trial Required)

Federal funding opportunity PA-25-306 from National Institutes of Health (Department of Health and Human Services).

Apply on Grants.gov →Application closes January 7, 2028

Posted
December 18, 2024
Closes
January 7, 2028
Cost sharing
No
Instrument
Grant
Assistance listing
93.213, 93.393, 93.855, 93.840, 93.273, 93.846, 93.286, 93.399, 93.279, 93.113, 93.172, 93.307, 93.838, 93.233, 93.839, 93.866, 93.143, 93.173, 93.837, 93.395, 93.865, 93.394, 93.879, 93.242, 93.396, 93.361, 93.867
Category
Education, Environment, Health, Income Security and Social Services
Archives
February 12, 2028

Program funding history

Awards made under Assistance Listing 93.213 across FY2024–FY2026, from public federal spending records.

FY2024 obligated
$118.3M
FY2025 obligated
$115.4M
FY2026 (to date) obligated
$53.3M
Awards in window
697

Top recipients: University of California, San Diego, The General Hospital Corporation, Yale Univ, Regents of the University of California, San Francisco, the, The Spaulding Rehabilitation Hospital Corporation

Source: USAspending.gov · refreshed August 2026

Synopsis

The NIH Exploratory/Developmental Grant supports exploratory and developmental research projects by providing support for the early and conceptual stages of these projects. These studies may involve considerable risk but may lead to a breakthrough in a particular area, or to the development of novel techniques, agents, methodologies, models, or applications that could have a major impact on a field of biomedical, behavioral, or clinical research. This Parent Notice of Funding Opportunity requires that at least 1 clinical trial be proposed. The proposed project must be related to the programmatic interests of one or more of the participating NIH Institutes and Centers (ICs) based on their scientific missions.Applicants should note that some ICs (see Related Notices) only accept applications proposing mechanistic studies that meet NIH's definition of a clinical trial through this funding opportunity announcement.

Who can apply

Other Eligible Applicants include the following: Alaska Native and Native Hawaiian Serving Institutions; Asian American Native American Pacific Islander Serving Institutions (AANAPISISs); Eligible Agencies of the Federal Government; Faith-based or Community-based Organizations; Hispanic-serving Institutions; Historically Black Colleges and Universities (HBCUs); Indian/Native American Tribal Governments (Other than Federally Recognized); Non-domestic (non-U.S.) Entities (Foreign Organizations); Regional Organizations; Tribally Controlled Colleges and Universities (TCCUs) ; U.S. Territory or Possession.

How to apply

Applications go through the official government listing. Grants Radar links you straight to the source — applying is free.

View on Grants.gov   Full announcement

Agency contact: National Institutes of Health · [email protected] · 301-402-2541

New to federal funding? How to read an announcement · Who can apply · How grants work

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