Open

NIH Exploratory/Developmental Research Project Grant (Parent R21 Clinical Trial Required)

Federal funding opportunity PA-25-306 from National Institutes of Health (Department of Health and Human Services).

Apply on Grants.gov →Application closes January 7, 2028

Posted: December 18, 2024
Closes: January 7, 2028
Cost sharing: No
Instrument: Grant
Assistance listing: 93.213, 93.393, 93.855, 93.840, 93.273, 93.846, 93.286, 93.399, 93.279, 93.113, 93.172, 93.307, 93.838, 93.233, 93.839, 93.866, 93.143, 93.173, 93.837, 93.395, 93.865, 93.394, 93.879, 93.242, 93.396, 93.361, 93.867
Category: Education, Environment, Health, Income Security and Social Services
Archives: February 12, 2028

Program funding history

Awards made under Assistance Listing 93.213 (one of 27 on this opportunity) across FY2025–FY2027, from public federal spending records.

FY2025 obligated: $115.4M
FY2026 obligated: $119M
FY2027 (to date) obligated: $0
Awards in window: 635

Top recipients: University of California, San Diego, The General Hospital Corporation, Yale Univ, The Spaulding Rehabilitation Hospital Corporation, University of California Irvine

Source: USAspending.gov · refreshed October 2026 · Program page: awards, recipients and the opportunities under this listing →

Synopsis

The NIH Exploratory/Developmental Grant supports exploratory and developmental research projects by providing support for the early and conceptual stages of these projects. These studies may involve considerable risk but may lead to a breakthrough in a particular area, or to the development of novel techniques, agents, methodologies, models, or applications that could have a major impact on a field of biomedical, behavioral, or clinical research. This Parent Notice of Funding Opportunity requires that at least 1 clinical trial be proposed. The proposed project must be related to the programmatic interests of one or more of the participating NIH Institutes and Centers (ICs) based on their scientific missions. Applicants should note that some ICs (see Related Notices) only accept applications proposing mechanistic studies that meet NIH's definition of a clinical trial through this funding opportunity announcement.

Who can apply

Native American tribal governments (Federally recognized)
Special district governments
Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education
Public housing authorities/Indian housing authorities
City or township governments
Independent school districts
Public and State controlled institutions of higher education
Native American tribal organizations (other than Federally recognized tribal governments)
For profit organizations other than small businesses
Private institutions of higher education
State governments
Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education
County governments
Small businesses
Others (see text field entitled "Additional Information on Eligibility" for clarification)

Other Eligible Applicants include the following: Alaska Native and Native Hawaiian Serving Institutions; Asian American Native American Pacific Islander Serving Institutions (AANAPISISs); Eligible Agencies of the Federal Government; Faith-based or Community-based Organizations; Hispanic-serving Institutions; Historically Black Colleges and Universities (HBCUs); Indian/Native American Tribal Governments (Other than Federally Recognized); Non-domestic (non-U.S.) Entities (Foreign Organizations); Regional Organizations; Tribally Controlled Colleges and Universities (TCCUs) ; U.S. Territory or Possession.

How to apply

Applications go through the official government listing. Grants Radar links you straight to the source — applying is free.

View on Grants.gov Full announcement

Agency contact: National Institutes of Health · [email protected] · 301-402-2541

New to federal funding? How to read an announcement · Who can apply · How grants work

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