Blueprint MedTech Translator (UG3/UH3 - Clinical Trial Optional)

Federal funding opportunity PAR-25-383 from National Institutes of Health (Department of Health and Human Services).

Apply on Grants.gov →Application closes January 28, 2028

Posted: June 17, 2025
Closes: January 28, 2028
Cost sharing: No
Instrument: Cooperative Agreement
Assistance listing: 93.279, 93.242, 93.865, 93.286, 93.853, 93.867, 93.866, 93.121, 93.213, 93.273
Category: Education, Health, Income Security and Social Services
Archives: March 4, 2028

Program funding history

Awards made under Assistance Listing 93.279 across FY2024–FY2026, from public federal spending records.

FY2024 obligated: $1.5B
FY2025 obligated: $1.5B
FY2026 (to date) obligated: $754.3M
Awards in window: 5,529

Top recipients: Yale Univ, University of California, San Diego, The Johns Hopkins University, University of Pittsburgh - of the Commonwealth System of Higher Education, Regents of the University of Michigan

Source: USAspending.gov · refreshed July 2026

Synopsis

The purpose of this announcement is to encourage investigators to pursue translational activities and clinical feasibility studies to advance the development of therapeutic, and diagnostic devices for disorders that affect the nervous or neuromuscular systems. Activities supported in this program include implementation of clinical prototype devices, non-clinical safety and efficacy testing, design verification and validation activities, obtaining an Investigational Device Exemption (IDE) for a Significant Risk (SR) study or Institutional Review Board (IRB) approval for a Non-Significant Risk (NSR) study, as well as a subsequent clinical feasibility study. The clinical study is expected to provide information about the device function or final design that cannot be practically obtained through additional non-clinical assessments (e.g., bench top or animal studies) due to the novelty of the device or its intended use. This FOA is a milestone-driven cooperative agreement program and will involve participation of NIH program staff in negotiating the final project plan before award and monitoring of research progress. Participants in Blueprint MedTech receive funding for all activities to be conducted in their own laboratories. In addition, applicants will collaborate with NIH-funded consultants to receive assistance with specialty areas including regulatory, reimbursement, intellectual property, commercialization, and strategic partnerships. Participants can also augment their project with NIH contract research organizations that specialize in large animal testing, sterilization testing, biocompatibility assessment, manufacturing, and medical monitoring. Individuals, institutions, or businesses developing their own devices or that already have established collaborations with device manufacturers are welcome to apply directly to this NOFO or any of the companion opportunities. For more information see BP MedTech website.

Who can apply

Others (see text field entitled "Additional Information on Eligibility" for clarification)
State governments
City or township governments
Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education
For profit organizations other than small businesses
County governments
Public housing authorities/Indian housing authorities
Public and State controlled institutions of higher education
Native American tribal organizations (other than Federally recognized tribal governments)
Native American tribal governments (Federally recognized)
Independent school districts
Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education
Special district governments
Private institutions of higher education
Small businesses

Other Eligible Applicants include the following: Alaska Native and Native Hawaiian Serving Institutions; Asian American Native American Pacific Islander Serving Institutions (AANAPISISs); Eligible Agencies of the Federal Government; Faith-based or Community-based Organizations; Hispanic-serving Institutions; Historically Black Colleges and Universities (HBCUs); Indian/Native American Tribal Governments (Other than Federally Recognized); Non-domestic (non-U.S.) Entities (Foreign Organizations); Regional Organizations; Tribally Controlled Colleges and Universities (TCCUs) ; U.S. Territory or Possession.

How to apply

Applications go through the official government listing. Grants Radar links you straight to the source.

View on Grants.gov Full announcement

Agency contact: National Institutes of Health · grantsinfo@nih.gov · 301-402-2541

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