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BRAIN Initiative Connectivity across Scales (BRAIN CONNECTS): Specialized Projects for Scalable Technologies (U01 Clinical Trial Not Allowed)

Federal funding opportunity RFA-NS-27-015 from National Institutes of Health (Department of Health and Human Services).

Apply on Grants.gov →Application closes October 4, 2027

Posted: May 28, 2026
Closes: October 4, 2027
Program funding: $10,000,000
Cost sharing: No
Instrument: Cooperative Agreement
Assistance listing: 93.279, 93.242, 93.853, 93.867, 93.286, 93.372, 93.866, 93.865, 93.173, 93.213, 93.273
Category: Health
Archives: December 3, 2027

Program funding history

Awards made under Assistance Listing 93.279 (one of 11 on this opportunity) across FY2025–FY2027, from public federal spending records.

FY2025 obligated: $1.5B
FY2026 obligated: $1.5B
FY2027 (to date) obligated: $0
Awards in window: 4,922

Top recipients: Yale Univ, The Johns Hopkins University, University of California, San Diego, University of Pittsburgh - of the Commonwealth System of Higher Education, Regents of the University of Michigan

Source: USAspending.gov · refreshed October 2026 · Program page: awards, recipients and the opportunities under this listing →

Synopsis

This funding announcement, issued by the Brain Research through Advancing Innovative Neurotechnologies® (BRAIN) Initiative, seeks transformative, cutting-edge, and innovative research that embraces new technologies, ideas, and approaches to understand brain circuit function and contributions to behavior. It is a component of the BRAIN Initiative Connectivity Across Scales (BRAIN CONNECTS) Program, which aims to lay the scientific foundation for the next generation of neural circuit-based approaches for preventing and treating devastating brain disorders. This Notice of Funding Opportunity (NOFO) supports Specialized Projects to develop current or emerging technologies to generate comprehensive atlases of brain connectivity, with an emphasis on human, non-human primate (NHP), and mouse. Projects using other species are also permitted, if their use is well justified and the goal is to test and validate approaches that can be generalized across species. Applications may address any aspect(s) of brain connectivity and associated data pipelines, including data collection, reconstruction, analysis, integration, dissemination, and interpretation, to enable faster, more precise, and more cost-effective generation and interpretation of brain-wide wiring diagrams. Funded projects will be integrated into the BRAIN CONNECTS Network consisting of projects funded under this and preceding BRAIN CONNECTS NOFOs, as a coordinated effort aimed at developing the capabilities to generate wiring diagrams that can span entire brains across multiple scales.

Who can apply

City or township governments
Private institutions of higher education
Special district governments
Others (see text field entitled "Additional Information on Eligibility" for clarification)
For profit organizations other than small businesses
Native American tribal organizations (other than Federally recognized tribal governments)
Public and State controlled institutions of higher education
Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education
County governments
Independent school districts
Native American tribal governments (Federally recognized)
Public housing authorities/Indian housing authorities
Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education
Small businesses
State governments

Refer to Section III. Eligibility Information in the NOFO for additional information on eligibility. Foreign Organizations/International Collaborations: Non-domestic (non-U.S.) Entities (Foreign Organizations) are eligible to apply. Non-domestic (non-U.S.) components of U.S. Organizations are eligible to apply. Foreign components, as defined in the NIH Grants Policy Statement, are not allowed.

How to apply

Applications go through the official government listing. Grants Radar links you straight to the source — applying is free.

View on Grants.gov

Agency contact: National Institutes of Health · [email protected] · 301-402-2541

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