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Forecasted

Small Business Transition Grant for New Entrepreneurs (Parent R41/R42 Clinical Trial Optional)

Federal funding opportunity PAR-27-040 from National Institutes of Health.

View forecast on Grants.gov →Forecasted — not yet open

Posted
May 27, 2026
Closes
See announcement
Cost sharing
No
Instrument
Grant
Assistance listing
93.837, 93.846, 93.121, 93.361, 93.859, 93.113, 93.233, 93.838, 93.839, 93.866, 93.273, 93.350, 93.879, 93.213, 93.279, 93.840, 93.172, 93.173, 93.865, 93.867
Category
Health

Program funding history

Awards made under Assistance Listing 93.837 across FY2024–FY2026, from public federal spending records.

FY2024 obligated
$3B
FY2025 obligated
$3B
FY2026 (to date) obligated
$1.3B
Awards in window
11,869

Top recipients: Brigham & Womens Hospital Inc, Regents of the University of Michigan, Trustees of the University of Pennsylvania, the, The Trustees of Columbia University in the City of New York, The Leland Stanford Junior University

Source: USAspending.gov · refreshed July 2026

Synopsis

The National Institutes of Health (NIH), including the participating Institutes, Centers and Offices, intends to publish a Notice of Funding Opportunity (NOFO) to invite eligible United States small business concerns (SBCs) to submit Small Business Technology Transfer (STTR) Phase I, and Fast-Track grant applications for the Small Business Transition Grant. Through this NOFO, NIH will support early-career scientists transitioning to entrepreneurship. In addition to funding research and development efforts at the SBC, a major component of this NOFO is entrepreneurial training, mentoring, and career development of the PD/PI.

Applications are not being solicited at this time. Notice is being provided to allow potential applicants sufficient time to develop responsive projects, including identification of complementary industry mentors and career development resources. This NOFO will utilize the R41/R42 activity code. United States small businesses that have the research capabilities and technological expertise to contribute to the R&D mission(s) of the NIH awarding components identified in this NOFO are encouraged to begin to consider applying for this new NOFO. This opportunity is available to first-time Principal Investigators, and key personnel must include a mentor with measurable effort committed to the project. 

Who can apply

Only United States small business concerns (SBCs), as defined by the Small Business Administration (SBA)(sbir.gov/apply) are eligible to submit applications for this opportunity. Individuals are eligible to serve as the PD/PI if they have never been an independent PD/PI on an NIH or CDC research, or corresponding non-NIH peer-reviewed research grant, and are a U.S. Citizen or Lawful Permanent Resident.

How to apply

Applications go through the official government listing. Grants Radar links you straight to the source.

View on Grants.gov

Agency contact: NIH SEED (Small business Education and Entrepreneurial Development) Office of Extramural Research (OER) · SEEDinfo@nih.gov · 301-827-8595

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