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NHLBI Early Phase Clinical Trials for Therapeutics and/or Diagnostics for HLBS Disorders (R61/R33 Clinical Trial Required)

Federal funding opportunity PAR-25-026 from National Institutes of Health (Department of Health and Human Services).

Apply on Grants.gov →Application closes January 7, 2027

Posted: December 5, 2024
Closes: January 7, 2027
Cost sharing: No
Instrument: Grant
Assistance listing: 93.840, 93.233, 93.839, 93.837, 93.838
Category: Health
Archives: February 12, 2027

Program funding history

Awards made under Assistance Listing 93.840 across FY2024–FY2026, from public federal spending records.

FY2024 obligated: $1.2M
FY2025 obligated: $2.1M
FY2026 (to date) obligated: $0
Awards in window: 88

Top recipients: The Regents of the University of Colorado, Indiana Department of Health, Minnesota Department of Health, Michigan Public Health Institute, City of Philadelphia

Source: USAspending.gov · refreshed August 2026

Synopsis

The objective of this funding opportunity is to support investigator-initiated, Phase I clinical trials for diagnostic and therapeutic interventions for heart, lung, blood, and sleep (HLBS) disorders in adults and children. In addition to supporting clinical trial start-up and implementation activities, this FOA will provide support for final stage preclinical activities needed for the implementation of the proposed trial. All the activities proposed in the R61 phase must be directly related to the therapeutic/diagnostic in preparation for the clinical trial. The proposed trial can be single or multisite. This NOFO will utilize a bi-phasic, milestone-driven mechanism of award where the first phase can be used to finalize required pre-trial activities such as stability, shipping studies, and site training.

Who can apply

State governments
Public and State controlled institutions of higher education
County governments
Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education
Private institutions of higher education
Native American tribal governments (Federally recognized)
Special district governments
City or township governments
Others (see text field entitled "Additional Information on Eligibility" for clarification)
Independent school districts
Public housing authorities/Indian housing authorities
Native American tribal organizations (other than Federally recognized tribal governments)
Small businesses
For profit organizations other than small businesses
Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education

Other Eligible Applicants include the following: Alaska Native and Native Hawaiian Serving Institutions; Asian American Native American Pacific Islander Serving Institutions (AANAPISISs); Eligible Agencies of the Federal Government; Faith-based or Community-based Organizations; Hispanic-serving Institutions; Historically Black Colleges and Universities (HBCUs); Indian/Native American Tribal Governments (Other than Federally Recognized); Non-domestic (non-U.S.) Entities (Foreign Organizations); Regional Organizations; Tribally Controlled Colleges and Universities (TCCUs) ; U.S. Territory or Possession.

How to apply

Applications go through the official government listing. Grants Radar links you straight to the source — applying is free.

View on Grants.gov Full announcement

Agency contact: National Institutes of Health · [email protected] · 301-402-2541

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