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INCLUDE Project: Clinical Trials Phased Awards for Down syndrome Research (R61/R33 Clinical Trial Required)

Federal funding opportunity RFA-OD-27-005 from National Institutes of Health (Department of Health and Human Services).

Apply on Grants.gov →Application closes June 15, 2028

Posted: May 13, 2026
Closes: June 15, 2028
Program funding: $3,000,000
Expected awards: 4
Cost sharing: No
Instrument: Grant
Assistance listing: 93.395, 93.866, 93.839, 93.838, 93.846, 93.840, 93.173, 93.310, 93.847, 93.837, 93.233, 93.350, 93.865
Category: Health
Archives: August 14, 2028

Program funding history

Awards made under Assistance Listing 93.395 across FY2024–FY2026, from public federal spending records.

FY2024 obligated: $1.1B
FY2025 obligated: $1.3B
FY2026 (to date) obligated: $825.6M
Awards in window: 4,065

Top recipients: The Univeristy of Texas M.d. Anderson Cancer Center, Dana-farber Cancer Institute, Inc., Icahn School of Medicine at Mount Sinai, Fred Hutchinson Cancer Center, Sloan-kettering Institute for Cancer Research

Source: USAspending.gov · refreshed August 2026

Synopsis

The NIH INvestigation of Co-occurring conditions across the Lifespan to Understand Down syndromE (INCLUDE) Project seeks to improve health and quality-of-life for individuals with Down syndrome. The purpose of this Notice of Funding Opportunity (NOFO) encourages Exploratory/Developmental Phased Innovation (R61/R33) grant applications to support development of clinical trials to treat critical and co-occurring health conditions in individuals with Down syndrome. The proposed research aims should be milestone-driven. The total project period for an application submitted in response to this NOFO may not exceed five years. This NOFO provides support for up to two years (R61 phase) for preliminary/developmental/planning studies, followed by possible transition to clinical trial support (R33) of up to three years, although the total duration of the award may not exceed five years. This NOFO requires measurable R61 milestones.

Who can apply

Others (see text field entitled "Additional Information on Eligibility" for clarification)
Special district governments
Independent school districts
City or township governments
County governments
Public housing authorities/Indian housing authorities
Native American tribal organizations (other than Federally recognized tribal governments)
Public and State controlled institutions of higher education
Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education
For profit organizations other than small businesses
Small businesses
State governments
Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education
Native American tribal governments (Federally recognized)
Private institutions of higher education

Refer to Section III. Eligibility Information in the NOFO for additional information on eligibility.Foreign Organizations/International Collaborations:Non-domestic (non-U.S.) Entities (Foreign Organizations) are eligible to apply.Non-domestic (non-U.S.) components of U.S. Organizations are eligible to apply.Foreign components, as defined in the NIH Grants Policy Statement, are allowed.

How to apply

Applications go through the official government listing. Grants Radar links you straight to the source — applying is free.

View on Grants.gov

Agency contact: National Institutes of Health · [email protected] · 301-402-2541

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