NHLBI Clinical Trial Pilot Studies (R34 Clinical Trial Optional)

Federal funding opportunity PAR-25-032 from National Institutes of Health (Department of Health and Human Services).

Apply on Grants.gov →Application closes January 7, 2027

Posted: December 18, 2024
Closes: January 7, 2027
Cost sharing: No
Instrument: Grant
Assistance listing: 93.838, 93.840, 93.839, 93.233, 93.837
Category: Health
Archives: February 12, 2027

Program funding history

Awards made under Assistance Listing 93.838 across FY2024–FY2026, from public federal spending records.

FY2024 obligated: $-47,224
FY2025 obligated: $-250,767
FY2026 (to date) obligated: $0
Awards in window: 1,105

Top recipients: Rutgers, the State University, University of Rochester, Trustees of Indiana University, National Jewish Health, The Trustees of Columbia University in the City of New York

Source: USAspending.gov · refreshed July 2026

Synopsis

This Notice of Funding Opportunity Announcement (NOFO) intends to supports studies that are both necessary and sufficient to inform the planning of a Phase II-IV clinical trial within NHLBI's mission. The NHLBI expects that applications to this NOFO will describe the planned clinical trial and in so doing demonstrate that the proposed (R34) research is scientifically necessary to design or plan the subsequent trial. Furthermore, this NOFO will support research projects that are designed to provide results that will be sufficient to inform the future trial without further studies. The planned Phase II, III, or IV trial must be primarily intended to test the efficacy, safety, clinical management, or implementation of intervention(s) in the prevention and/or treatment of heart, lung, blood, and sleep disorders. In contrast to the study start up or preparation phase of NHLBI funding opportunities for clinical trials (as described at https://www.nhlbi.nih.gov/grants-and-training/funding-opportunities-and-contacts/clinical-trials-optimization), the R34 mechanism is intended to provide new information that answers a scientific or operational question(s) which may be pragmatic in nature and, therefore, informs the final development of a Phase II-IV clinical trial. Regardless of the results of the R34, support of the proposed future clinical trial will require a new application.

Who can apply

County governments
Independent school districts
Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education
For profit organizations other than small businesses
Public and State controlled institutions of higher education
Public housing authorities/Indian housing authorities
Private institutions of higher education
Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education
City or township governments
Special district governments
Small businesses
Native American tribal governments (Federally recognized)
Native American tribal organizations (other than Federally recognized tribal governments)
State governments
Others (see text field entitled "Additional Information on Eligibility" for clarification)

Other Eligible Applicants include the following: Alaska Native and Native Hawaiian Serving Institutions; Asian American Native American Pacific Islander Serving Institutions (AANAPISISs); Eligible Agencies of the Federal Government; Faith-based or Community-based Organizations; Hispanic-serving Institutions; Historically Black Colleges and Universities (HBCUs); Indian/Native American Tribal Governments (Other than Federally Recognized); Non-domestic (non-U.S.) Entities (Foreign Organizations); Regional Organizations; Tribally Controlled Colleges and Universities (TCCUs) ; U.S. Territory or Possession; Non-domestic (non-U.S.) Entities (Foreign Organizations) are not eligible to apply. Non-domestic (non-U.S.) components of U.S. Organizations are eligible to apply. Foreign components, as defined in the NIH Grants Policy Statement, are allowed.

How to apply

Applications go through the official government listing. Grants Radar links you straight to the source.

View on Grants.gov Full announcement

Agency contact: National Institutes of Health · grantsinfo@nih.gov · 301-402-2541

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