Open

NHLBI TOPMed: Omics Phenotypes of Heart, Lung, and Blood Disorders (X01 - Clinical Trial Not Allowed)

Federal funding opportunity PAR-25-447 from National Institutes of Health (Department of Health and Human Services).

Apply on Grants.gov →Application closes May 8, 2028

Posted: September 22, 2025
Closes: May 8, 2028
Cost sharing: No
Instrument: Grant
Assistance listing: 93.837, 93.838, 93.839, 93.840, 93.233
Category: Health
Archives: June 13, 2028

Program funding history

Awards made under Assistance Listing 93.837 (one of 5 on this opportunity) across FY2025–FY2027, from public federal spending records.

FY2025 obligated: $3B
FY2026 obligated: $3B
FY2027 (to date) obligated: $0
Awards in window: 10,712

Top recipients: Trustees of the University of Pennsylvania, the, Brigham & Womens Hospital Inc, University of Pittsburgh - of the Commonwealth System of Higher Education, Regents of the University of Michigan, The Leland Stanford Junior University

Source: USAspending.gov · refreshed October 2026 · Program page: awards, recipients and the opportunities under this listing →

Synopsis

This Notice of Funding Opportunity (NOFO) invites applications to use NHLBI-funded TransOmics for Precision Medicine (TOPMed) program to generate a large volume of integrated genetic and multi-omics data to facilitate discovery of the molecular mechanisms of Heart, Lung, Blood, and Sleep (HLBS) disorders. No funding will be provided under this NOFO. The genomic data and related phenotypic data will be deposited in a public NIH-designated controlled-access database such as the database for Genotypes and Phenotypes (dbGaP) and NHLBIs BioData Catalyst (BDC). The overall goal is to move from simply cataloguing genetic associations to understanding how genetic factors contribute to HLBS diseases at the molecular and cellular levels. This transformation will help move TOPMed from genetic Map to Mechanism with potential applications of AI and ML tool sets where possible, enabling functional genomics research that will accelerate mechanistic personalized medicine

Who can apply

Native American tribal governments (Federally recognized)
For profit organizations other than small businesses
Independent school districts
Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education
Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education
State governments
Native American tribal organizations (other than Federally recognized tribal governments)
Others (see text field entitled "Additional Information on Eligibility" for clarification)
County governments
Special district governments
Private institutions of higher education
Public and State controlled institutions of higher education
City or township governments
Public housing authorities/Indian housing authorities
Small businesses

Other Eligible Applicants include the following: Alaska Native and Native Hawaiian Serving Institutions; Asian American Native American Pacific Islander Serving Institutions (AANAPISISs); Eligible Agencies of the Federal Government; Faith-based or Community-based Organizations; Hispanic-serving Institutions; Historically Black Colleges and Universities (HBCUs); Indian/Native American Tribal Governments (Other than Federally Recognized); Non-domestic (non-U.S.) Entities (Foreign Organizations); Regional Organizations; Tribally Controlled Colleges and Universities (TCCUs) ; U.S. Territory or Possession.

How to apply

Applications go through the official government listing. Grants Radar links you straight to the source — applying is free.

View on Grants.gov Full announcement

Agency contact: National Institutes of Health · [email protected] · 301-402-2541

New to federal funding? How to read an announcement · Who can apply · How grants work

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