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NHLBI TOPMed: Omics Phenotypes of Heart, Lung, and Blood Disorders (X01 - Clinical Trial Not Allowed)

Federal funding opportunity PAR-25-447 from National Institutes of Health (Department of Health and Human Services).

Apply on Grants.gov →Application closes May 8, 2028

Posted
September 22, 2025
Closes
May 8, 2028
Cost sharing
No
Instrument
Grant
Assistance listing
93.837, 93.838, 93.839, 93.840, 93.233
Category
Health
Archives
June 13, 2028

Program funding history

Awards made under Assistance Listing 93.837 across FY2024–FY2026, from public federal spending records.

FY2024 obligated
$3B
FY2025 obligated
$3B
FY2026 (to date) obligated
$1.3B
Awards in window
11,869

Top recipients: Brigham & Womens Hospital Inc, Regents of the University of Michigan, Trustees of the University of Pennsylvania, the, The Trustees of Columbia University in the City of New York, The Leland Stanford Junior University

Source: USAspending.gov · refreshed July 2026

Synopsis

This Notice of Funding Opportunity (NOFO) invites applications to use NHLBI-funded TransOmics for Precision Medicine (TOPMed) program to generate a large volume of integrated genetic and multi-omics data to facilitate discovery of the molecular mechanisms of Heart, Lung, Blood, and Sleep (HLBS) disorders. No funding will be provided under this NOFO. The genomic data and related phenotypic data will be deposited in a public NIH-designated controlled-access database such as the database for Genotypes and Phenotypes (dbGaP) and NHLBIs BioData Catalyst (BDC). The overall goal is to move from simply cataloguing genetic associations to understanding how genetic factors contribute to HLBS diseases at the molecular and cellular levels. This transformation will help move TOPMed from genetic Map to Mechanism with potential applications of AI and ML tool sets where possible, enabling functional genomics research that will accelerate mechanistic personalized medicine

Who can apply

Other Eligible Applicants include the following: Alaska Native and Native Hawaiian Serving Institutions; Asian American Native American Pacific Islander Serving Institutions (AANAPISISs); Eligible Agencies of the Federal Government; Faith-based or Community-based Organizations; Hispanic-serving Institutions; Historically Black Colleges and Universities (HBCUs); Indian/Native American Tribal Governments (Other than Federally Recognized); Non-domestic (non-U.S.) Entities (Foreign Organizations); Regional Organizations; Tribally Controlled Colleges and Universities (TCCUs) ; U.S. Territory or Possession.

How to apply

Applications go through the official government listing. Grants Radar links you straight to the source.

View on Grants.gov   Full announcement

Agency contact: National Institutes of Health · grantsinfo@nih.gov · 301-402-2541

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