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PRIMED-AI: Data-to-Model Academic-Industrial Partnerships (D2M-AIP) for Precision Medicine with AI: Integrating Imaging with Multimodal Data (UG3/UH3 Clinical Trial Optional)

Federal funding opportunity RFA-RM-27-012 from National Institutes of Health (Department of Health and Human Services).

Apply on Grants.gov →Application closes October 19, 2026

Posted: June 30, 2026
Closes: October 19, 2026
Expected awards: 8
Cost sharing: No
Instrument: Cooperative Agreement
Assistance listing: 93.310
Category: Health
Archives: December 18, 2026

Program funding history

Awards made under Assistance Listing 93.310 across FY2024–FY2026, from public federal spending records.

FY2024 obligated: $1.2B
FY2025 obligated: $1B
FY2026 (to date) obligated: $564M
Awards in window: 4,858

Top recipients: Washington University, the, The Leland Stanford Junior University, Yale Univ, The Johns Hopkins University, New York University

Source: USAspending.gov · refreshed August 2026

Synopsis

The overarching goal of this notice of funding opportunity (NOFO) and its companion opportunities is to establish the Precision Medicine with AI: Integrating Imaging with Multimodal Data (PRIMED-AI) Program to support development of innovative, reliable, cost-effective, and sustainable multimodal AI-based clinical decision support (CDS) tools. PRIMED-AI CDS tools are based on the integration of clinical imaging with other types of multimodal health data to enhance care for patients with a wide range of health conditions. The PRIMED-AI Program seeks to catalyze the adoption of AI-based CDS tools into clinical workflows to enable novel personalized medicine strategies that address significant health challenges. The purpose of this Notice of Funding Opportunity (NOFO) is to catalyze the development and testing of Artificial Intelligence (AI)-enabled, image-centered, multimodal Clinical Decision Support (CDS) tools, developed in pursuance as Software as a Medical Device (SaMD). These projects are expected to have high potential for demonstrable, positive impact on patient outcomes and/or healthcare processes.

Who can apply

Private institutions of higher education
Public housing authorities/Indian housing authorities
Others (see text field entitled "Additional Information on Eligibility" for clarification)
County governments
Small businesses
Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education
Public and State controlled institutions of higher education
City or township governments
State governments
Special district governments
Native American tribal governments (Federally recognized)
Independent school districts
For profit organizations other than small businesses
Native American tribal organizations (other than Federally recognized tribal governments)
Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education

Refer to Section III. Eligibility Information in the NOFO for additional information on eligibility.Foreign Organizations/International Collaborations:Non-domestic (non-U.S.) Entities (Foreign Organizations) are eligible to apply.Non-domestic (non-U.S.) components of U.S. Organizations are eligible to apply.Foreign components, as defined in the NIH Grants Policy Statement, are allowed.

How to apply

Applications go through the official government listing. Grants Radar links you straight to the source — applying is free.

View on Grants.gov

Agency contact: National Institutes of Health · [email protected] · 301-402-2541

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