Open

INCLUDE Project: Transformative Research Awards for Down syndrome (R01 Clinical Trial Not Allowed)

Federal funding opportunity RFA-OD-27-004 from National Institutes of Health (Department of Health and Human Services).

Apply on Grants.gov →Application closes June 15, 2028

Posted: May 12, 2026
Closes: June 15, 2028
Award ceiling: $500,000
Program funding: $3,000,000
Expected awards: 4
Cost sharing: No
Instrument: Grant
Assistance listing: 93.867, 93.310, 93.846, 93.855, 93.395, 93.847, 93.351, 93.838, 93.866, 93.837, 93.121, 93.233, 93.839, 93.865, 93.879, 93.350, 93.173, 93.242, 93.840
Category: Health
Archives: August 14, 2028

Program funding history

Awards made under Assistance Listing 93.867 (one of 19 on this opportunity) across FY2025–FY2027, from public federal spending records.

FY2025 obligated: $696.7M
FY2026 obligated: $693.8M
FY2027 (to date) obligated: $0
Awards in window: 3,058

Top recipients: The Johns Hopkins University, The Leland Stanford Junior University, Jaeb Center for Health Research Foundation, Inc., Regents of the University of California, San Francisco, the, University of California, Los Angeles

Source: USAspending.gov · refreshed October 2026 · Program page: awards, recipients and the opportunities under this listing →

Synopsis

The NIH INvestigation of Co-occurring conditions across the Lifespan to Understand Down syndromE (INCLUDE) Project seeks to improve health and quality-of-life for individuals with Down syndrome. The purpose of this Notice of Funding Opportunity (NOFO) is to solicit Transformative Research Award applications to support individual scientists or groups of scientists proposing groundbreaking, exceptionally innovative, original, and/or unconventional research that has the potential to create new scientific paradigms, establish entirely new and improved clinical approaches, or develop transformative technologies related to Down syndrome. Applications are welcome in all topics relevant to Down syndrome-related research or its co-occurring conditions. No preliminary data are required. Projects must clearly demonstrate, based on the strength of the logic, a compelling potential to produce a major impact in research related to Down syndrome.

Who can apply

Private institutions of higher education
Independent school districts
Others (see text field entitled "Additional Information on Eligibility" for clarification)
Native American tribal organizations (other than Federally recognized tribal governments)
State governments
Small businesses
Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education
Public and State controlled institutions of higher education
Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education
County governments
City or township governments
Special district governments
Native American tribal governments (Federally recognized)
For profit organizations other than small businesses
Public housing authorities/Indian housing authorities

Refer to Section III. Eligibility Information in the NOFO for additional information on eligibility. Foreign Organizations/International Collaborations: Non-domestic (non-U.S.) Entities (Foreign Organizations) are eligible to apply. Non-domestic (non-U.S.) components of U.S. Organizations are eligible to apply. Foreign components, as defined in the NIH Grants Policy Statement, are allowed.

How to apply

Applications go through the official government listing. Grants Radar links you straight to the source — applying is free.

View on Grants.gov

Agency contact: National Institutes of Health · [email protected] · 301-402-2541

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