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INCLUDE Project: Transformative Research Awards for Down syndrome (R01 Clinical Trial Not Allowed)

Federal funding opportunity RFA-OD-27-004 from National Institutes of Health (Department of Health and Human Services).

Apply on Grants.gov →Application closes June 15, 2028

Posted
May 12, 2026
Closes
June 15, 2028
Award ceiling
$500,000
Program funding
$3,000,000
Expected awards
4
Cost sharing
No
Instrument
Grant
Assistance listing
93.867, 93.310, 93.846, 93.855, 93.395, 93.847, 93.351, 93.838, 93.866, 93.837, 93.121, 93.233, 93.839, 93.865, 93.879, 93.350, 93.173, 93.242, 93.840
Category
Health
Archives
August 14, 2028

Program funding history

Awards made under Assistance Listing 93.867 across FY2024–FY2026, from public federal spending records.

FY2024 obligated
$689M
FY2025 obligated
$696.7M
FY2026 (to date) obligated
$332.4M
Awards in window
3,337

Top recipients: The Johns Hopkins University, The Leland Stanford Junior University, Regents of the University of California, San Francisco, the, Jaeb Center for Health Research Foundation, Inc., Duke University

Source: USAspending.gov · refreshed July 2026

Synopsis

The NIH INvestigation of Co-occurring conditions across the Lifespan to Understand Down syndromE (INCLUDE) Project seeks to improve health and quality-of-life for individuals with Down syndrome. The purpose of this Notice of Funding Opportunity (NOFO) is to solicit Transformative Research Award applications to support individual scientists or groups of scientists proposing groundbreaking, exceptionally innovative, original, and/or unconventional research that has the potential to create new scientific paradigms, establish entirely new and improved clinical approaches, or develop transformative technologies related to Down syndrome. Applications are welcome in all topics relevant to Down syndrome-related research or its co-occurring conditions. No preliminary data are required. Projects must clearly demonstrate, based on the strength of the logic, a compelling potential to produce a major impact in research related to Down syndrome.

Who can apply

Refer to Section III. Eligibility Information in the NOFO for additional information on eligibility.Foreign Organizations/International Collaborations:Non-domestic (non-U.S.) Entities (Foreign Organizations) are eligible to apply.Non-domestic (non-U.S.) components of U.S. Organizations are eligible to apply.Foreign components, as defined in the NIH Grants Policy Statement, are allowed.

How to apply

Applications go through the official government listing. Grants Radar links you straight to the source.

View on Grants.gov

Agency contact: National Institutes of Health · DownSyndromeINCLUDE@mail.nih.gov · 301-402-2541

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