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INCLUDE Project: Exploratory/Developmental Research Awards for Down syndrome (R21 Clinical Trial Not Allowed)

Federal funding opportunity RFA-OD-27-003 from National Institutes of Health (Department of Health and Human Services).

Apply on Grants.gov →Application closes June 15, 2028

Posted: May 12, 2026
Closes: June 15, 2028
Award ceiling: $200,000
Program funding: $1,000,000
Expected awards: 5
Cost sharing: No
Instrument: Grant
Assistance listing: 93.351, 93.865, 93.867, 93.838, 93.866, 93.837, 93.840, 93.839, 93.121, 93.233, 93.846, 93.879, 93.395, 93.173, 93.310, 93.855
Category: Health
Archives: August 14, 2028

Program funding history

Awards made under Assistance Listing 93.351 across FY2024–FY2026, from public federal spending records.

FY2024 obligated: $279M
FY2025 obligated: $281.4M
FY2026 (to date) obligated: $231.5M
Awards in window: 1,149

Top recipients: University of California, Davis, Oregon Health & Science University, University of Washington, Emory University, The Administrators of Tulane Educational Fund

Source: USAspending.gov · refreshed August 2026

Synopsis

The NIH INvestigation of Co-occurring conditions across the Lifespan to Understand Down syndromE (INCLUDE) Project seeks to improve health and quality-of-life for individuals with Down syndrome. This Notice of Funding Opportunity (NOFO) invites researchers to submit applications for support of new exploratory and developmental research projects that address critical needs for Down syndrome projects, as articulated in the INCLUDE Project objectives. For example, such projects could assess the feasibility of a novel area of investigation or a new experimental system that has the potential to enhance health-related research. Another example could include the unique and innovative use of an existing methodology to explore a new scientific area. These studies may involve considerable risk but may lead to a breakthrough in a particular area, or to the development of novel techniques, agents, methodologies, models, or applications that could have a major impact on a field of biomedical, behavioral, or clinical research.

Who can apply

City or township governments
Public housing authorities/Indian housing authorities
Native American tribal organizations (other than Federally recognized tribal governments)
Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education
Public and State controlled institutions of higher education
Others (see text field entitled "Additional Information on Eligibility" for clarification)
Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education
Small businesses
Native American tribal governments (Federally recognized)
State governments
County governments
For profit organizations other than small businesses
Special district governments
Private institutions of higher education
Independent school districts

Refer to Section III. Eligibility Information in the NOFO for additional information on eligibility.Foreign Organizations/International Collaborations:Non-domestic (non-U.S.) Entities (Foreign Organizations) are eligible to apply.Non-domestic (non-U.S.) components of U.S. Organizations are eligible to apply.Foreign components, as defined in the NIH Grants Policy Statement, are allowed.

How to apply

Applications go through the official government listing. Grants Radar links you straight to the source — applying is free.

View on Grants.gov

Agency contact: National Institutes of Health · [email protected] · 301-402-2541

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