Collaborative Opportunities for Multiple-disciplinary, Bold, and Innovative Neuroscience (COMBINE) (RM1 Clinical Trial Optional)
- Posted
- August 28, 2025
- Closed
- See announcement
- Cost sharing
- No
- Instrument
- Grant
- Assistance listing
- 93.853
- Category
- Health
Program funding history
Awards made under Assistance Listing 93.853 across FY2025–FY2027, from public federal spending records.
- FY2025 obligated
- $1.8B
- FY2026 obligated
- $2B
- FY2027 (to date) obligated
- $0
- Awards in window
- 8,124
Top recipients: The General Hospital Corporation, Regents of the University of California, San Francisco, the, The Johns Hopkins University, Regents of the University of Michigan, Washington University, the
Source: USAspending.gov · refreshed October 2026 · Program page: awards, recipients and the opportunities under this listing →
Synopsis
The National Institute of Neurological Disorders and Stroke (NINDS) intends to publish a Notice of Funding Opportunity (NOFO) to solicit applications from highly-integrated transdisciplinary team science led by 3-6 PDs/PIs to pursue a single focused goal to overcome persistent barriers, challenge orthodoxies, achieve paradigm-shifts, or develop new foundational principles in neuroscience. Within five-years, the team must deliver outcomes significantly advancing the NINDS mission and transform knowledge and practice, ranging from fundamental neuroscience to human health. The research question(s) should be of sufficient scope and complexity to necessitate an innovative convergence of disciplines, expertise, and coordination, beyond the scope of traditional R01 or Program Project/Center grant mechanisms. Applications are not being solicited at this time. Notice is being provided to allow potential applicants sufficient time to develop meaningful collaborations and responsive projects. This NOFO will utilize the RM1 activity code. Investigators with expertise and insights into this area of neuroscience and neurology are encouraged to begin to consider applying for this new NOFO. In addition, collaborative investigations from newly formed or established teams, combining expertise in various fields of basic, clinical, and translational domains of neuroscience will be encouraged, and these investigators should also begin considering applying for this application.
Who can apply
- Public and State controlled institutions of higher education
- Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education
- Private institutions of higher education
- Independent school districts
- For profit organizations other than small businesses
- County governments
- Special district governments
- Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education
- Public housing authorities/Indian housing authorities
- Small businesses
- Others (see text field entitled "Additional Information on Eligibility" for clarification)
- State governments
- Native American tribal governments (Federally recognized)
- Native American tribal organizations (other than Federally recognized tribal governments)
- City or township governments
Other Eligible ApplicantsIndian/Native American Tribal Governments (Other than Federally Recognized);Eligible Agencies of the Federal Government;U.S. Territory or Possession;Faith-based or Community-based Organizations;Regional Organizations;Non-domestic (non-U.S.) Entities (Foreign Institutions).
The official record
Grants.gov published the official terms and dates of this opportunity; this page keeps them as they were listed.
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