HEAL Initiative: Pain Management Effectiveness Research Network: Clinical Trial Planning and Implementation Cooperative Agreement (UG3/UH3 Clinical Trial Required)
View forecast on Grants.gov →Forecasted — not yet open
- Posted
- August 28, 2025
- Closes
- See announcement
- Cost sharing
- No
- Instrument
- Cooperative Agreement
- Assistance listing
- 93.853
- Category
- Health
Program funding history
Awards made under Assistance Listing 93.853 across FY2025–FY2027, from public federal spending records.
- FY2025 obligated
- $1.8B
- FY2026 obligated
- $2B
- FY2027 (to date) obligated
- $0
- Awards in window
- 8,124
Top recipients: The General Hospital Corporation, Regents of the University of California, San Francisco, the, The Johns Hopkins University, Regents of the University of Michigan, Washington University, the
Source: USAspending.gov · refreshed October 2026 · Program page: awards, recipients and the opportunities under this listing →
Synopsis
The National Institute of Neurological Disorders and Stroke (NINDS), with the National Center for Advancing Translational Sciences (NCATS), National Institute on Aging (NIA), National Institute of Dental and Craniofacial Research (NIDCR), National Center for Complementary and Integrative Health (NCCIH), National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS), and the Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) intends to publish a Notice of Funding Opportunity (NOFO) to solicit applications for the conduct of large-scale, multisite clinical trials (CTs) that will inform clinicians about the efficacy or effectiveness of interventions or management strategies that reduce opioid use, improve functional outcomes and reduce pain across the continuum of acute to chronic pain associated with many types of diseases, conditions, or pain presenting as a disease itself. This NOFO will be a continuation of the HEAL Initiative Pain Management Effectiveness Research Network (ERN). The goal of this NOFO will be to expand the suite of evidence-based effective therapeutics to alleviate pain for multiple pain conditions to benefit patients and their families. Applications are not being solicited at this time. Notice is being provided to allow potential applicants sufficient time to develop meaningful collaborations and responsive projects. This NOFO will utilize the UG3/UH3 activity code. Investigators with expertise and insights into this area of performing effectiveness trials for pain management interventions are encouraged to begin to consider applying for this new NOFO. In addition, collaborative investigations combining expertise in testing existing pharmaceutical, repurposed therapeutics and/or existing devices will be encouraged, and these investigators should also begin considering applying for this application.
Who can apply
- Special district governments
- Public and State controlled institutions of higher education
- State governments
- Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education
- Small businesses
- County governments
- Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education
- Public housing authorities/Indian housing authorities
- For profit organizations other than small businesses
- Native American tribal organizations (other than Federally recognized tribal governments)
- Others (see text field entitled "Additional Information on Eligibility" for clarification)
- Native American tribal governments (Federally recognized)
- City or township governments
- Independent school districts
- Private institutions of higher education
Other Eligible ApplicantsIndian/Native American Tribal Governments (Other than Federally Recognized);Eligible Agencies of the Federal Government;U.S. Territory or Possession;Faith-based or Community-based Organizations;Regional Organizations;Non-domestic (non-U.S.) Entities (Foreign Institutions).
How to apply
Applications go through the official government listing. Grants Radar links you straight to the source — applying is free.
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