HEAL Initiative: Non-addictive Analgesic Therapeutics Development [Small Molecules and Biologics] to Treat Pain (UG3/UH3 Clinical Trial Optional)
- Posted
- October 31, 2023
- Closed
- May 8, 2025
- Cost sharing
- No
- Instrument
- Cooperative Agreement
- Assistance listing
- 93.837, 93.313, 93.395, 93.838, 93.233, 93.867, 93.846, 93.847, 93.840, 93.273, 93.213, 93.121, 93.865, 93.866, 93.279, 93.853, 93.839
- Archives
- June 7, 2025
Program funding history
Awards made under Assistance Listing 93.837 (one of 17 on this opportunity) across FY2025–FY2027, from public federal spending records.
- FY2025 obligated
- $3B
- FY2026 obligated
- $3B
- FY2027 (to date) obligated
- $0
- Awards in window
- 10,712
Top recipients: Trustees of the University of Pennsylvania, the, Brigham & Womens Hospital Inc, University of Pittsburgh - of the Commonwealth System of Higher Education, Regents of the University of Michigan, The Leland Stanford Junior University
Source: USAspending.gov · refreshed October 2026 · Program page: awards, recipients and the opportunities under this listing →
Synopsis
Reissue of RFA-NS-20-010: The purpose of this funding opportunity announcement (FOA) is to support preclinical optimization and development of safe, effective, and non-addictive small molecule and biologic therapeutics to treat pain. The goal of the program is to accelerate the optimization and development of promising small molecule and biologic hits/leads towards clinical trials. Applicants must have a promising hit/lead, robust biological rationale for the intended approach, and identified assays for optimization of the agent. The scope of this program includes optimization and early development activities, IND-enabling studies, and assembly of Investigational New Drug (IND) application. This is a milestone-driven phased cooperative agreement program involving participation of NIH program staff in the development of the project plan and monitoring of research progress.
Who can apply
- Public housing authorities/Indian housing authorities
- County governments
- Native American tribal governments (Federally recognized)
- Independent school districts
- Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education
- Private institutions of higher education
- Special district governments
- For profit organizations other than small businesses
- Others (see text field entitled "Additional Information on Eligibility" for clarification)
- Native American tribal organizations (other than Federally recognized tribal governments)
- Public and State controlled institutions of higher education
- Small businesses
- City or township governments
- State governments
- Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education
Other Eligible Applicants include the following: Alaska Native and Native Hawaiian Serving Institutions; Asian American Native American Pacific Islander Serving Institutions (AANAPISISs); Eligible Agencies of the Federal Government; Faith-based or Community-based Organizations; Hispanic-serving Institutions; Historically Black Colleges and Universities (HBCUs); Indian/Native American Tribal Governments (Other than Federally Recognized); Non-domestic (non-U.S.) Entities (Foreign Organizations); Regional Organizations; Tribally Controlled Colleges and Universities (TCCUs) ; U.S. Territory or Possession; Non-domestic (non-U.S.) Entities (Foreign Organizations) are not eligible to apply. Non-domestic (non-U.S.) components of U.S. Organizations are not eligible to apply. Foreign components, as defined in the NIH Grants Policy Statement, are allowed.
The official record
Grants.gov published the official terms and dates of this opportunity; this page keeps them as they were listed.
View on Grants.gov Full announcement
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Similar grants
- HEAL Initiative: Non-addictive Analgesic Therapeutics Development [Small Molecules and Biologics] to Treat Pain (UG3/UH3 Clinical Trial Optional)
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