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HEAL Initiative: Studies to Enable Analgesic Discovery (R61/R33 - Clinical Trial Not Allowed)

Federal funding opportunity RFA-NS-25-023 from National Institutes of Health (Department of Health and Human Services).

Apply on Grants.gov →Application closes January 15, 2027

Posted
September 18, 2024
Closes
January 15, 2027
Award ceiling
$350,000
Cost sharing
No
Instrument
Grant
Assistance listing
93.846, 93.121, 93.213, 93.273, 93.847, 93.865, 93.393, 93.866, 93.853, 93.867
Category
Education, Food and Nutrition, Health, Income Security and Social Services
Archives
February 20, 2027

Program funding history

Awards made under Assistance Listing 93.846 across FY2024–FY2026, from public federal spending records.

FY2024 obligated
$535.2M
FY2025 obligated
$537.1M
FY2026 (to date) obligated
$251.2M
Awards in window
2,932

Top recipients: Trustees of the University of Pennsylvania, the, Regents of the University of California, San Francisco, the, Brigham & Womens Hospital Inc, Regents of the University of Michigan, The General Hospital Corporation

Source: USAspending.gov · refreshed July 2026

Synopsis

This funding opportunity is part of a suite of NOFOs within the NIH HEAL Initiative to support the development of safe, effective, and non-addictive therapeutics to treat pain. The goal is to encourage initial translational efforts that will support a drug discovery program and advance projects to the point where they meet the entry criteria for the Pain Therapeutics Development Program. The scope will therefore be focused on development of assays to support a distinct testing funnel, screening efforts to identify hits, and initial characterization of hits and potential therapeutic agents (including small molecules, biologics, and natural products).

Who can apply

Other Eligible Applicants include the following: Alaska Native and Native Hawaiian Serving Institutions; Asian American Native American Pacific Islander Serving Institutions (AANAPISISs); Eligible Agencies of the Federal Government; Faith-based or Community-based Organizations; Hispanic-serving Institutions; Historically Black Colleges and Universities (HBCUs); Indian/Native American Tribal Governments (Other than Federally Recognized); Non-domestic (non-U.S.) Entities (Foreign Organizations); Regional Organizations; Tribally Controlled Colleges and Universities (TCCUs) ; U.S. Territory or Possession; Non-domestic (non-U.S.) Entities (Foreign Organizations) are not eligible to apply. Non-domestic (non-U.S.) components of U.S. Organizations are not eligible to apply.

How to apply

Applications go through the official government listing. Grants Radar links you straight to the source.

View on Grants.gov   Full announcement

Agency contact: National Institutes of Health · grantsinfo@nih.gov · 301-402-2541

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