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Catalyze: Product Definition for Small Molecules, Biologics, and Combination Products - Preliminary Product/Lead Series Identification and Combination Product Prototype (R33 - Clinical Trial Not Allowed)

Federal funding opportunity RFA-HL-26-018 from National Institutes of Health (Department of Health and Human Services).

Apply on Grants.gov →Application closes December 23, 2027

Posted
November 22, 2024
Closes
December 23, 2027
Cost sharing
No
Instrument
Grant
Assistance listing
93.855, 93.838, 93.233, 93.837, 93.839
Category
Health
Archives
January 28, 2028

Program funding history

Awards made under Assistance Listing 93.855 across FY2024–FY2026, from public federal spending records.

FY2024 obligated
$4.1B
FY2025 obligated
$4.2B
FY2026 (to date) obligated
$2.3B
Awards in window
14,249

Top recipients: Fred Hutchinson Cancer Center, The Johns Hopkins University, Regents of the University of California, San Francisco, the, Washington University, the, Duke University

Source: USAspending.gov · refreshed July 2026

Synopsis

The goal of the NHLBI Catalyze Program is to provide a comprehensive suite of support and services to facilitate the transition of basic science discoveries into viable diagnostic and therapeutic candidates that have been cleared for human testing, and to develop translational researchers fluent in product development and entrepreneurship. This specific Catalyze Product Definition initiative will provide the early stage translational support needed for the activities required to identify and characterize potential therapeutic candidates and combination products to treat HLBS diseases and disorders. This initiative has a companion initiative that supports development of devices and diagnostics and is also part of a suite of innovation grants to advance projects to the point where they can meet the entry criteria for the NHLBI Catalyze Preclinical Program.

Who can apply

Other Eligible Applicants include the following: Alaska Native and Native Hawaiian Serving Institutions; Asian American Native American Pacific Islander Serving Institutions (AANAPISISs); Eligible Agencies of the Federal Government; Faith-based or Community-based Organizations; Hispanic-serving Institutions; Historically Black Colleges and Universities (HBCUs); Indian/Native American Tribal Governments (Other than Federally Recognized); Non-domestic (non-U.S.) Entities (Foreign Organizations); Regional Organizations; Tribally Controlled Colleges and Universities (TCCUs) ; U.S. Territory or Possession; Non-domestic (non-U.S.) Entities (Foreign Organizations) are not eligible to apply.Non-domestic (non-U.S.) components of U.S. Organizations are eligible to apply.Foreign components, as defined in the NIH Grants Policy Statement, are allowed.

How to apply

Applications go through the official government listing. Grants Radar links you straight to the source.

View on Grants.gov   Full announcement

Agency contact: National Institutes of Health · grantsinfo@nih.gov · 301-402-2541

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