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HEAL Initiative: Non-addictive Analgesic Therapeutics Development [Small Molecules and Biologics] to Treat Pain (UG3/UH3 Clinical Trial Optional)

Federal funding opportunity RFA-NS-27-007 from National Institutes of Health (Department of Health and Human Services).

Apply on Grants.gov →Application closes February 20, 2029

Posted
June 16, 2026
Closes
February 20, 2029
Program funding
$11,000,000
Expected awards
3
Cost sharing
No
Instrument
Cooperative Agreement
Assistance listing
93.395, 93.866, 93.839, 93.867, 93.838, 93.846, 93.840, 93.213, 93.273, 93.853, 93.837, 93.233, 93.279, 93.865
Category
Health
Archives
April 21, 2029

Program funding history

Awards made under Assistance Listing 93.395 across FY2024–FY2026, from public federal spending records.

FY2024 obligated
$1.1B
FY2025 obligated
$1.3B
FY2026 (to date) obligated
$507.4M
Awards in window
3,932

Top recipients: The Univeristy of Texas M.d. Anderson Cancer Center, Dana-farber Cancer Institute, Inc., Icahn School of Medicine at Mount Sinai, Fred Hutchinson Cancer Center, Sloan-kettering Institute for Cancer Research

Source: USAspending.gov · refreshed July 2026

Synopsis

The purpose of this Notice of Funding Opportunity (NOFO) is to support the preclinical optimization and development of safe, effective, and non-addictive small molecule and biologic therapeutics for the treatment of pain. The goal of the program is to accelerate the advancement of promising early-stage therapeutic candidates and facilitate their readiness for Phase II clinical trials. Applicants must have a promising small molecule or biologic lead candidate for optimization, a strong biological rationale for the proposed approach, and established assays to guide the optimization process. The scope of the program includes lead optimization, early-stage development activities, IND-enabling studies, development of pharmacodynamic and/or target engagement biomarkers, preparation and submission of an Investigational New Drug (IND) application, and Phase I clinical testing. This is a milestone-driven, phased cooperative agreement program that involves active participation by NIH program staff in project planning and ongoing monitoring of research progress.

Who can apply

Refer to Section III. Eligibility Information in the NOFO for additional information on eligibility.Foreign Organizations/International CollaborationsNon-domestic (non-U.S.) Entities (Foreign Organizations) are not eligible to apply.Non-domestic (non-U.S.) components of U.S. Organizations are not eligible to apply.Foreign components, as defined in the NIH Grants Policy Statement, are not allowed.

How to apply

Applications go through the official government listing. Grants Radar links you straight to the source.

View on Grants.gov

Agency contact: National Institutes of Health · PTDP@ninds.nih.gov · 301-402-2541

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