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Addressing Methodological Challenges with Clinical Trials of Rapid-Acting Psychotropic Interventional Drugs (RAPIDs) (R01 Clinical Trial Required)

Federal funding opportunity RFA-MH-27-135 from National Institutes of Health (Department of Health and Human Services).

Apply on Grants.gov →Application closes October 11, 2026

Posted
April 29, 2026
Closes
October 11, 2026
Program funding
$5,500,000
Expected awards
5
Cost sharing
No
Instrument
Grant
Assistance listing
93.242, 93.279
Category
Health
Archives
December 10, 2026

Program funding history

Awards made under Assistance Listing 93.242 across FY2024–FY2026, from public federal spending records.

FY2024 obligated
$1.8B
FY2025 obligated
$1.8B
FY2026 (to date) obligated
$945.1M
Awards in window
7,145

Top recipients: Yale Univ, University of Pittsburgh - of the Commonwealth System of Higher Education, Icahn School of Medicine at Mount Sinai, University of California, Los Angeles, Washington University, the

Source: USAspending.gov · refreshed July 2026

Synopsis

The purpose of this notice of funding opportunity (NOFO) is to elucidate the key components of the therapeutic effects of rapid-acting psychotropic interventional drugs (RAPIDs) by addressing the methodological challenges involved with these clinical trials. In addition, this NOFO seeks to advance understanding of how RAPIDs and adjunctive psychosocial interventions can be optimally delivered, monitored, and sustained over time to enhance effectiveness and generalizability. The NOFO will support studies designed to enhance the rigor of RAPID clinical trial design, which will ultimately increase the interpretability of the data and the generalizability of the results.

Who can apply

Refer to Section III. Eligibility Information in the NOFO for additional information on eligibility.Foreign Organizations/International CollaborationsNon-domestic (non-U.S.) Entities (Foreign Organizations) are not eligible to apply.Non-domestic (non-U.S.) components of U.S. Organizations are not eligible to apply.Foreign components, as defined in the NIH Grants Policy Statement, are not allowed.

How to apply

Applications go through the official government listing. Grants Radar links you straight to the source.

View on Grants.gov

Agency contact: National Institutes of Health · DTRcommunications@nih.gov · 301-402-2541

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