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Cooperative Agreement for In Vivo High-Resolution Imaging for Inner Ear Visualization (U01 Clinical Trial Required)

Federal funding opportunity RFA-DC-25-003 from National Institutes of Health (Department of Health and Human Services).

Apply on Grants.gov →Application closes October 1, 2026

Posted: January 6, 2025
Closes: October 1, 2026
Award ceiling: $500,000
Program funding: $500,000
Cost sharing: No
Instrument: Cooperative Agreement
Assistance listing: 93.173
Category: Health
Archives: November 6, 2026

Program funding history

Awards made under Assistance Listing 93.173 across FY2024–FY2026, from public federal spending records.

FY2024 obligated: $416.3M
FY2025 obligated: $416.1M
FY2026 (to date) obligated: $337.5M
Awards in window: 2,284

Top recipients: The Johns Hopkins University, Massachusetts Eye and Ear Infirmary, University of Pittsburgh - of the Commonwealth System of Higher Education, University of Wisconsin System, The Leland Stanford Junior University

Source: USAspending.gov · refreshed August 2026

Synopsis

This funding opportunity aims to support high risk clinical trials for the development of in vivo high-resolution structural and functional imaging technologies for the living human inner ear. Proposed projects should focus on improving the resolution of current imaging techniques or developing new imaging techniques that can visualize inner ear structures in vivo with significantly greater detail and accuracy than currently possible. Structural and functional aspects, including visualizing dynamic elements, are important to developing new and improved techniques. Projects may also focus on developing new imaging probes or contrast agents that can enhance visualization of the inner ear structures. Research supported in response to this RFA is expected to significantly advance the ability to visualize auditory and vestibular components, such as hair cells, otoliths, membranes, ions, and vasculature, in detail in awake patients in a clinical setting using non-invasive techniques. To achieve this goal, a multidisciplinary team approach that takes advantage of the expertise of each team member is highly encouraged. Studies in humans must be proposed to develop,advance, or test the needed technology. Any intermediate studies must articulate a clear path of the proposed methodology to application in awake humans or define the limitations and the usefulness in anesthetized humans.

Who can apply

Small businesses
City or township governments
Native American tribal governments (Federally recognized)
Private institutions of higher education
Special district governments
For profit organizations other than small businesses
State governments
Public housing authorities/Indian housing authorities
Native American tribal organizations (other than Federally recognized tribal governments)
Others (see text field entitled "Additional Information on Eligibility" for clarification)
County governments
Public and State controlled institutions of higher education
Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education
Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education
Independent school districts

Other Eligible Applicants include the following: Alaska Native and Native Hawaiian Serving Institutions; Asian American Native American Pacific Islander Serving Institutions (AANAPISISs); Eligible Agencies of the Federal Government; Faith-based or Community-based Organizations; Hispanic-serving Institutions; Historically Black Colleges and Universities (HBCUs); Indian/Native American Tribal Governments (Other than Federally Recognized); Non-domestic (non-U.S.) Entities (Foreign Organizations); Regional Organizations; Tribally Controlled Colleges and Universities (TCCUs) ; U.S. Territory or Possession.

How to apply

Applications go through the official government listing. Grants Radar links you straight to the source — applying is free.

View on Grants.gov Full announcement

Agency contact: National Institutes of Health · [email protected] · 301-402-2541

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