NIH Blueprint Initiative: Tools for Germline Gene Editing in the Nervous System
View forecast on Grants.gov →Forecasted — not yet open
- Posted
- May 7, 2026
- Closes
- See announcement
- Award ceiling
- $1,200,000
- Program funding
- $7,200,000
- Expected awards
- 4
- Cost sharing
- No
- Instrument
- Cooperative Agreement
- Assistance listing
- 93.279
- Category
- Health
Program funding history
Awards made under Assistance Listing 93.279 across FY2025–FY2027, from public federal spending records.
- FY2025 obligated
- $1.5B
- FY2026 obligated
- $1.5B
- FY2027 (to date) obligated
- $0
- Awards in window
- 4,922
Top recipients: Yale Univ, The Johns Hopkins University, University of California, San Diego, University of Pittsburgh - of the Commonwealth System of Higher Education, Regents of the University of Michigan
Source: USAspending.gov · refreshed October 2026 · Program page: awards, recipients and the opportunities under this listing →
Synopsis
The NIH Blueprint (a consortium of NIH Institutes that support neuroscience research) seeks to advance its mission by supporting the development, optimization, validation, and application of germline and somatic transgenic and gene-editing approaches in experimental systems modeling key features of human brain anatomy, circuitry, cognition, behavior, and lifespan. This initiative will build on the previously supported marmoset gene-editing infrastructure, by integrating New Approach Methodologies (NAMs) with other models, to advance understanding of human brain function and disease, including human-derived NAMs for cross-species comparisons across development. Many mechanisms of complex conditions, such as autism spectrum disorders, schizophrenia, and other behavioral/developmental disorders, cannot yet be captured in NAMs and are therefore high priorities for research investment to accelerate development and validation of human-derived NAMs. Appropriate models should be used and clearly justified as necessary for questions involving neuroanatomy, circuit function, cognition, behavior, or lifespan phenotyping related to human brain disease and function. Grant authorities are as follows: 42 U.S.C 241 and 284.
Who can apply
- City or township governments
- Public and State controlled institutions of higher education
- Private institutions of higher education
- Native American tribal governments (Federally recognized)
- For profit organizations other than small businesses
- Special district governments
- State governments
- Public housing authorities/Indian housing authorities
- Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education
- Others (see text field entitled "Additional Information on Eligibility" for clarification)
- County governments
- Native American tribal organizations (other than Federally recognized tribal governments)
- Independent school districts
- Small businesses
- Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education
Other Eligible ApplicantsIndian/Native American Tribal Governments (Other than Federally Recognized);Eligible Agencies of the Federal Government;U.S. Territory or Possession;Faith-based or Community-based Organizations;Regional Organizations;Non-domestic (non-U.S.) Entities (Foreign Institutions).
How to apply
Applications go through the official government listing. Grants Radar links you straight to the source — applying is free.
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