Neural Ensembles & Used Substances (NExUS) Collaboratory: Building a Multimodal Inventory of Cell Ensembles Encoding the Effects of Addictive Substances
Federal funding opportunity RFA-DA-27-010 from National Institutes of Health.
View forecast on Grants.gov →Forecasted — not yet open
- Posted
- September 11, 2025
- Closes
- See announcement
- Award ceiling
- $700,000
- Expected awards
- 4
- Cost sharing
- No
- Instrument
- Cooperative Agreement
- Assistance listing
- 93.279
- Category
- Health
Program funding history
Awards made under Assistance Listing 93.279 across FY2024–FY2026, from public federal spending records.
- FY2024 obligated
- $1.5B
- FY2025 obligated
- $1.5B
- FY2026 (to date) obligated
- $754.3M
- Awards in window
- 5,529
Top recipients: Yale Univ, University of California, San Diego, The Johns Hopkins University, University of Pittsburgh - of the Commonwealth System of Higher Education, Regents of the University of Michigan
Source: USAspending.gov · refreshed July 2026
Synopsis
The National Institute on Drug Abuse (NIDA) seeks to advance its mission by supporting the expansion of the Collaboratory on Neural Ensembles & Used Substances (NExUS), an effort to build a knowledgebase of the neural cell populations and computations altered by substance-associated experiences, and underlying neurobehavioral states characteristic of addiction, or protective against it. This notice is provided to allow prospective applicants to develop applications that achieve the following goals:
1) Collect and share granular datasets descriptive of neural cell populations tuned to tractable features of substance-related experiences
2) Integrate cell-resolved readouts of ensemble activity with other granular data modalities (e.g., molecular cell identity, epigenetic state, morphology, spatial localization or connectivity)
3) Develop tools for analysis and visualization of ensemble composition and geometry, and document their scalability
4) Inform and test models for the mechanisms whereby cells or motifs are recruited into coding ensembles
5) Enable synergies among NExUS-funded projects and with other cell atlasing efforts through coordination of outreach, data standards, analytics, common spatial frameworks, and reference taxonomies
Grant Authorities that allow NIDA to forecast this opportunity are as follows: Section 301 (42 U.S.C. § 241) and Section 405 (42 U.S.C. § 284).
Who can apply
- For profit organizations other than small businesses
- Special district governments
- Independent school districts
- Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education
- County governments
- Native American tribal organizations (other than Federally recognized tribal governments)
- Others (see text field entitled "Additional Information on Eligibility" for clarification)
- Public and State controlled institutions of higher education
- Private institutions of higher education
- Public housing authorities/Indian housing authorities
- City or township governments
- Native American tribal governments (Federally recognized)
- State governments
- Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education
- Small businesses
Other Eligible ApplicantsIndian/Native American Tribal Governments (Other than Federally Recognized);Eligible Agencies of the Federal Government;U.S. Territory or Possession;Faith-based or Community-based Organizations;Regional Organizations;Non-domestic (non-U.S.) Entities (Foreign Institutions).
How to apply
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