Glioblastoma Therapeutics Network (GTN; U19 Clinical Trial Required)
Federal funding opportunity RFA-CA-25-033 from National Institutes of Health.
View forecast on Grants.gov →Forecasted — not yet open
- Posted
- September 17, 2025
- Closes
- See announcement
- Cost sharing
- No
- Instrument
- Cooperative Agreement
- Assistance listing
- 93.394, 93.395
- Category
- Health
Program funding history
Awards made under Assistance Listing 93.394 across FY2024–FY2026, from public federal spending records.
- FY2024 obligated
- $533.3M
- FY2025 obligated
- $595.6M
- FY2026 (to date) obligated
- $227.4M
- Awards in window
- 2,123
Top recipients: Regents of the University of California, San Francisco, the, Fred Hutchinson Cancer Center, The Johns Hopkins University, The Leland Stanford Junior University, Sloan-kettering Institute for Cancer Research
Source: USAspending.gov · refreshed July 2026
Synopsis
Through this Notice of Funding Opportunity (NOFO), the National Cancer Institute (NCI) solicits applications for research on novel therapies for adult glioblastoma (GBM). The goal is to improve the treatment of adult GBM by developing novel effective agents that can cross the blood brain barrier (BBB) and testing them clinically. Successful early-stage trials of new drugs from this NOFO would transition seamlessly to later stage trials using well-established NCI clinical trial mechanisms.
To implement this concept, a highly collaborative GBM Therapeutics Network (GTN) of cross-cutting teams will be established, each team capable of driving therapeutic agent(s) from pre-clinical development, through IND studies, into pilot clinical studies in humans. Appropriate therapeutic agents include: (1) novel agents or (2) agents or combinations approved for other indications and repurposed for treatment of GBM following appropriate preclinical studies. The scope of the NOFO, from late pre-clinical through early (Phase 0/1) clinical studies, uniquely spans a gap in the GBM drug development process.
Who can apply
- Public housing authorities/Indian housing authorities
- Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education
- Private institutions of higher education
- Native American tribal governments (Federally recognized)
- County governments
- Native American tribal organizations (other than Federally recognized tribal governments)
- City or township governments
- Small businesses
- Public and State controlled institutions of higher education
- Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education
- State governments
- Others (see text field entitled "Additional Information on Eligibility" for clarification)
- Special district governments
- Independent school districts
- For profit organizations other than small businesses
Other Eligible ApplicantsIndian/Native American Tribal Governments (Other than Federally Recognized);Eligible Agencies of the Federal Government;U.S. Territory or Possession;Faith-based or Community-based Organizations;Regional Organizations;
How to apply
Applications go through the official government listing. Grants Radar links you straight to the source.
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