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HEAL Initiative: Pain Research Enhancement Program (PREP) (R15 Clinical Trial Optional)

Federal funding opportunity RFA-AT-25-003 from National Institutes of Health (Department of Health and Human Services).

Apply on Grants.gov →Application closes November 23, 2026

Posted: January 8, 2025
Closes: November 23, 2026
Award ceiling: $375,000
Cost sharing: No
Instrument: Grant
Assistance listing: 93.121, 93.865, 93.866, 93.213, 93.273, 93.846, 93.853
Category: Health, Income Security and Social Services
Archives: December 29, 2026

Program funding history

Awards made under Assistance Listing 93.121 across FY2024–FY2026, from public federal spending records.

FY2024 obligated: $379.1M
FY2025 obligated: $378.9M
FY2026 (to date) obligated: $266.9M
Awards in window: 2,392

Top recipients: Regents of the University of Michigan, Regents of the University of California, San Francisco, the, University of Pittsburgh - of the Commonwealth System of Higher Education, University of Southern California, Trustees of the University of Pennsylvania, the

Source: USAspending.gov · refreshed August 2026

Synopsis

The purpose of this initiative is to: (1) support the efforts by R15-eligible Principal Investigators (PIs) to conduct rigorous basic and/or mechanistic pain research projects; (2) promote integrated, interdisciplinary research partnerships between R15-eligible PIs and additional investigators from U.S. domestic institutions, and (3) enhance the pain research environment at the R15-eligible institution for health professional trainees or undergraduate and/or graduate students by actively engaging them in the proposed pain research projects.

Who can apply

Private institutions of higher education
Others (see text field entitled "Additional Information on Eligibility" for clarification)
Public and State controlled institutions of higher education

Other Eligible Applicants include the following: Alaska Native and Native Hawaiian Serving Institutions; Asian American Native American Pacific Islander Serving Institutions (AANAPISISs); Hispanic-serving Institutions; Historically Black Colleges and Universities (HBCUs); Tribally Controlled Colleges and Universities (TCCUs) ; Non-domestic (non-U.S.) Entities (Foreign Organizations) are not eligible to apply. Non-domestic (non-U.S.) components of U.S. Organizations are not eligible to apply. Foreign components, as defined in the NIH Grants Policy Statement, are allowed.

How to apply

Applications go through the official government listing. Grants Radar links you straight to the source — applying is free.

View on Grants.gov Full announcement

Agency contact: National Institutes of Health · [email protected] · 301-402-2541

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