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HEAL Initiative: Pain Research Enhancement Program (PREP) (R15 Clinical Trial Optional)

Federal funding opportunity RFA-AT-25-003 from National Institutes of Health (Department of Health and Human Services).

Apply on Grants.gov →Application closes November 23, 2026

Posted
January 8, 2025
Closes
November 23, 2026
Award ceiling
$375,000
Cost sharing
No
Instrument
Grant
Assistance listing
93.121, 93.865, 93.866, 93.213, 93.273, 93.846, 93.853
Category
Health, Income Security and Social Services
Archives
December 29, 2026

Program funding history

Awards made under Assistance Listing 93.121 across FY2024–FY2026, from public federal spending records.

FY2024 obligated
$379.1M
FY2025 obligated
$378.9M
FY2026 (to date) obligated
$179.8M
Awards in window
2,319

Top recipients: Regents of the University of Michigan, Regents of the University of California, San Francisco, the, University of Southern California, University of Pittsburgh - of the Commonwealth System of Higher Education, Trustees of the University of Pennsylvania, the

Source: USAspending.gov · refreshed July 2026

Synopsis

The purpose of this initiative is to: (1) support the efforts by R15-eligible Principal Investigators (PIs) to conduct rigorous basic and/or mechanistic pain research projects; (2) promote integrated, interdisciplinary research partnerships between R15-eligible PIs and additional investigators from U.S. domestic institutions, and (3) enhance the pain research environment at the R15-eligible institution for health professional trainees or undergraduate and/or graduate students by actively engaging them in the proposed pain research projects.

Who can apply

Other Eligible Applicants include the following: Alaska Native and Native Hawaiian Serving Institutions; Asian American Native American Pacific Islander Serving Institutions (AANAPISISs); Hispanic-serving Institutions; Historically Black Colleges and Universities (HBCUs); Tribally Controlled Colleges and Universities (TCCUs) ; Non-domestic (non-U.S.) Entities (Foreign Organizations) are not eligible to apply. Non-domestic (non-U.S.) components of U.S. Organizations are not eligible to apply. Foreign components, as defined in the NIH Grants Policy Statement, are allowed.

How to apply

Applications go through the official government listing. Grants Radar links you straight to the source.

View on Grants.gov   Full announcement

Agency contact: National Institutes of Health · grantsinfo@nih.gov · 301-402-2541

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