National Biomedical Research Centers (P50 Clinical Trial Optional)
View forecast on Grants.gov →Forecasted — not yet open
- Posted
- May 12, 2026
- Closes
- See announcement
- Award ceiling
- $11,405,967
- Award floor
- $7,955,376
- Expected awards
- 2
- Cost sharing
- No
- Instrument
- Grant
- Assistance listing
- 93.351
- Category
- Health
Program funding history
Awards made under Assistance Listing 93.351 across FY2025–FY2027, from public federal spending records.
- FY2025 obligated
- $281.4M
- FY2026 obligated
- $276.6M
- FY2027 (to date) obligated
- $0
- Awards in window
- 894
Top recipients: University of California, Davis, Oregon Health & Science University, University of Washington, Emory University, The Administrators of Tulane Educational Fund
Source: USAspending.gov · refreshed October 2026 · Program page: awards, recipients and the opportunities under this listing →
Synopsis
The National Biomedical Research Centers (NBRCs) are expected to provide scientific expertise, advanced equipment, infrastructure, and a range of well-characterized research models to researchers across the nation. Research at the NBRCs is supported by almost all NIH Institutes, as well as other federal agencies, including those that safeguard US national security interests. This NOFO emphasizes development of innovative human-based models and new technologies to reduce reliance on live research models. Applications must describe clear, actionable plans to reduce, refine, and replace whole-animal use by developing complementary and alternative approaches tailored to relevant use cases in biomedical research. Scientifically, the NBRCs function as centers of innovation in fundamental science as well as translational hubs that develop, refine, and test novel interventions for ultimate use in human patients. It is NIH’s intention that the NBRCs become leaders in the development and use of human-based approaches, including sophisticated in vitro and in silico models, known as New Approach Methodologies (NAMs). Clinical trials are allowed only as human-based NAMs, where applicable. This notice of funding opportunity (NOFO) is an open competition to increase opportunities for innovation, including NAMs research, at research centers with existing nonhuman primate colonies, and to further leverage existing capabilities in basic and translational research.
Who can apply
- Public and State controlled institutions of higher education
- Small businesses
- Native American tribal governments (Federally recognized)
- Private institutions of higher education
- Special district governments
- County governments
- For profit organizations other than small businesses
- Native American tribal organizations (other than Federally recognized tribal governments)
- City or township governments
- Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education
- State governments
- Independent school districts
- Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education
- Public housing authorities/Indian housing authorities
- Others (see text field entitled "Additional Information on Eligibility" for clarification)
Other Eligible ApplicantsIndian/Native American Tribal Governments (Other than Federally Recognized);Eligible Agencies of the Federal Government;U.S. Territory or Possession;Faith-based or Community-based Organizations;Regional Organizations;Non-domestic (non-U.S.) Entities (Foreign Institutions).
How to apply
Applications go through the official government listing. Grants Radar links you straight to the source — applying is free.
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