Early-Onset Cancers: Investigating Etiology, Mechanisms, and Early Detection Strategies (RP1 Clinical Trials Optional)
View forecast on Grants.gov →Forecasted — not yet open
- Posted
- March 10, 2026
- Closes
- See announcement
- Cost sharing
- No
- Instrument
- Grant
- Assistance listing
- 93.399, 93.393, 93.396
- Category
- Health
Program funding history
Awards made under Assistance Listing 93.399 across FY2024–FY2026, from public federal spending records.
- FY2024 obligated
- $167M
- FY2025 obligated
- $172.1M
- FY2026 (to date) obligated
- $9.6M
- Awards in window
- 151
Top recipients: Ecog-acrin Medical Research Foundation, Inc., Nrg Oncology Foundation Inc, Alliance Nctn Foundation, Fred Hutchinson Cancer Center, Oregon Health & Science University
Source: USAspending.gov · refreshed August 2026
Synopsis
Through this Notice of Funding Opportunity (NOFO), the National Cancer Institute (NCI) invites applications that investigate the etiology of sporadic non-hereditary early-onset cancers (EOCs: ages 18 to 49 years) and the underlying biological mechanisms that play a role in these cancers to inform prevention and control strategies. The proposed research is expected to advance the understanding of the unexplained rise of cancers in young adults. More specifically, studies should address one or more of the following: i) what modifiable exposures are driving the increase in the incidence of non-hereditary EOCs, and how do these factors vary by patient demographics? (ii) what biological mechanisms and host responses underly the increase in EOCs? and (iii) how can those at increased risk for developing EOCs be identified more effectively?
This NOFO consolidates exploratory/developmental and research project funding mechanisms to streamline the application process and sustain momentum in this critical research area. Applicants have the option of submitting either an exploratory/developmental research project with a project period of up to 2 years or a research project with a project period of 4 to 5 years.
Who can apply
- Small businesses
- County governments
- Special district governments
- Native American tribal organizations (other than Federally recognized tribal governments)
- Public and State controlled institutions of higher education
- Others (see text field entitled "Additional Information on Eligibility" for clarification)
- State governments
- For profit organizations other than small businesses
- Independent school districts
- Native American tribal governments (Federally recognized)
- Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education
- Private institutions of higher education
- City or township governments
- Public housing authorities/Indian housing authorities
- Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education
Other Eligible ApplicantsIndian/Native American Tribal Governments (Other than Federally Recognized);Eligible Agencies of the Federal Government;U.S. Territory or Possession;Regional Organizations;Non-domestic (non-U.S.) Entities (Foreign Institutions).
How to apply
Applications go through the official government listing. Grants Radar links you straight to the source — applying is free.
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