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Development of Interventions to Prevent and Treat Substance Use Disorders and Overdose (UG3/UH3 - Clinical Trial Optional)

Apply on Grants.gov →Application closes August 21, 2028

Posted
September 10, 2025
Closes
August 21, 2028
Award ceiling
$3,000,000
Cost sharing
No
Instrument
Cooperative Agreement
Assistance listing
93.279
Category
Education, Health
Archives
September 26, 2028

Program funding history

Awards made under Assistance Listing 93.279 across FY2024–FY2026, from public federal spending records.

FY2024 obligated
$1.5B
FY2025 obligated
$1.5B
FY2026 (to date) obligated
$1.1B
Awards in window
5,647

Top recipients: Yale Univ, University of California, San Diego, The Johns Hopkins University, University of Pittsburgh - of the Commonwealth System of Higher Education, Regents of the University of Michigan

Source: USAspending.gov · refreshed August 2026

Synopsis

The purpose of this Funding Opportunity (NOFO) is to solicit grant applications to support research on the discovery and development of interventions to prevent and/or treat substance use disorders (SUDs) and overdose, including medications and medical devices to treat co-morbid SUDs. This includes preclinical and clinical research studies that will have high impact and quickly yield the necessary results to advance candidate interventions closer to regulatory approval or clinical adoption. This NOFO will utilize the UG3/UH3 activity code.

Who can apply

Other Eligible Applicants include the following: Eligible Agencies of the Federal Government; Faith-based or Community-based Organizations; Indian/Native American Tribal Governments (Other than Federally Recognized); Non-domestic (non-U.S.) Entities (Foreign Organizations); Regional Organizations; U.S. Territory or Possession.

How to apply

Applications go through the official government listing. Grants Radar links you straight to the source — applying is free.

View on Grants.gov   Full announcement

Agency contact: National Institutes of Health · [email protected] · 301-402-2541

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