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Avant Garde/Avenir Awards for Investigators Conducting High Risk/High Reward Research on HIV and Substance Use (or Substance Use Disorders) (DP1 Clinical Trial Optional)

Federal funding opportunity PAR-27-026 from National Institutes of Health (Department of Health and Human Services).

Apply on Grants.gov →Application closes September 25, 2028

Posted
June 9, 2026
Closes
September 25, 2028
Cost sharing
No
Instrument
Grant
Assistance listing
93.279
Category
Health
Archives
November 24, 2028

Program funding history

Awards made under Assistance Listing 93.279 across FY2024–FY2026, from public federal spending records.

FY2024 obligated
$1.5B
FY2025 obligated
$1.5B
FY2026 (to date) obligated
$754.3M
Awards in window
5,529

Top recipients: Yale Univ, University of California, San Diego, The Johns Hopkins University, University of Pittsburgh - of the Commonwealth System of Higher Education, Regents of the University of Michigan

Source: USAspending.gov · refreshed July 2026

Synopsis

The purpose of this notice of funding opportunity (NOFO) is to support innovative basic, clinical, translational, and implementation science research relevant to HIV and substance use. This initiative encourages high risk high impact transformative studies that advance knowledge and strategies for HIV prevention, diagnosis, treatment and virus suppression in people who use substances and/or have a substance use disorder.

Who can apply

Refer to Section III. Eligibility Information in the NOFO for additional information on eligibility.Foreign Organizations/Foreign Collaborations:Non-domestic (non-U.S.) Entities (Foreign Organizations) are eligible to apply.Non-domestic (non-U.S.) components of U.S. Organizations are eligible to apply.Foreign components, as defined in the NIH Grants Policy Statement, are allowed.

How to apply

Applications go through the official government listing. Grants Radar links you straight to the source.

View on Grants.gov

Agency contact: National Institutes of Health · nidagmbemail@nida.nih.gov · 301-402-2541

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