Get alerts
Open

Avant Garde/Avenir Awards for Investigators Conducting High Risk/High Reward Research on HIV and Substance Use (or Substance Use Disorders) (DP1 Clinical Trial Optional)

Apply on Grants.gov →Application closes September 25, 2028

Posted
June 9, 2026
Closes
September 25, 2028
Cost sharing
No
Instrument
Grant
Assistance listing
93.279
Category
Health
Archives
November 24, 2028

Program funding history

Awards made under Assistance Listing 93.279 across FY2024–FY2026, from public federal spending records.

FY2024 obligated
$1.5B
FY2025 obligated
$1.5B
FY2026 (to date) obligated
$1.1B
Awards in window
5,647

Top recipients: Yale Univ, University of California, San Diego, The Johns Hopkins University, University of Pittsburgh - of the Commonwealth System of Higher Education, Regents of the University of Michigan

Source: USAspending.gov · refreshed August 2026

Synopsis

The purpose of this notice of funding opportunity (NOFO) is to support innovative basic, clinical, translational, and implementation science research relevant to HIV and substance use. This initiative encourages high risk high impact transformative studies that advance knowledge and strategies for HIV prevention, diagnosis, treatment and virus suppression in people who use substances and/or have a substance use disorder.

Who can apply

Refer to Section III. Eligibility Information in the NOFO for additional information on eligibility.Foreign Organizations/Foreign Collaborations:Non-domestic (non-U.S.) Entities (Foreign Organizations) are eligible to apply.Non-domestic (non-U.S.) components of U.S. Organizations are eligible to apply.Foreign components, as defined in the NIH Grants Policy Statement, are allowed.

How to apply

Applications go through the official government listing. Grants Radar links you straight to the source — applying is free.

View on Grants.gov

Agency contact: National Institutes of Health · [email protected] · 301-402-2541

Get grants like this every Tuesday — free

One email a week: the biggest new federal grants and what’s closing soon — the same list for everyone. Unsubscribe in one click.

The free edition carries one clearly labeled sponsor slot. No spam, ever. Privacy

Similar grants

Same-day alerts, matched to you

The free digest is weekly — the same list for everyone. Members get an alert the day a matching federal grant posts: we read every new Grants.gov posting and score it, personalized to your organization. Free for 30 days, then $19/mo founding rate locked for life — the rate holds while your subscription stays active (Terms). Card required, cancel any time before day 31.

See pricing