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Screening and Functional Validation of Genomic Variants Associated with Human Congenital Anomalies (R01 Clinical Trial Not Allowed)

Federal funding opportunity PAR-25-185 from National Institutes of Health (Department of Health and Human Services).

Apply on Grants.gov →Application closes January 7, 2028

Posted
October 30, 2024
Closes
January 7, 2028
Cost sharing
No
Instrument
Grant
Assistance listing
93.865, 93.121, 93.351
Category
Health, Income Security and Social Services
Archives
February 12, 2028

Program funding history

Awards made under Assistance Listing 93.865 across FY2024–FY2026, from public federal spending records.

FY2024 obligated
$1.2B
FY2025 obligated
$1.3B
FY2026 (to date) obligated
$548.5M
Awards in window
6,253

Top recipients: Regents of the University of Michigan, University of Washington, The Johns Hopkins University, Regents of the University of California, San Francisco, the, The Leland Stanford Junior University

Source: USAspending.gov · refreshed July 2026

Synopsis

Rapid advances in genotyping and next generation sequencing technologies have led to the identification of genetic variants that are associated with a wide variety of congenital defects including human congenital anomalies (HCAs), intellectual developmental disabilities (IDDs) and inborn errors of metabolism (IEMs). Large quantities of genomic data collected from pediatric congenital anomalies cohorts are available to the research community through several databases such as the Database of Genotypes and Phenotypes (dbGaP), the Gabriella Miller Kids First Data Resource Portal, the European Genome-Phenome Archive and Clinical Genome Resource (ClinGen). The purpose of this initiative is to promote the screening, functional validation and characterization of congenital anomaly-associated genetic variants identified through public facing databases and individual efforts using in-silico tools, appropriate animal models, in vitro systems or multi-pronged approaches. This initiative addresses a challenging gap between identifying sequence variations of potential interest and recognizing which of those variations have functional effects on the phenotype of interest.

Who can apply

Other Eligible Applicants include the following: Alaska Native and Native Hawaiian Serving Institutions; Asian American Native American Pacific Islander Serving Institutions (AANAPISISs); Eligible Agencies of the Federal Government; Faith-based or Community-based Organizations; Hispanic-serving Institutions; Historically Black Colleges and Universities (HBCUs); Indian/Native American Tribal Governments (Other than Federally Recognized); Non-domestic (non-U.S.) Entities (Foreign Organizations); Regional Organizations; Tribally Controlled Colleges and Universities (TCCUs) ; U.S. Territory or Possession.

How to apply

Applications go through the official government listing. Grants Radar links you straight to the source.

View on Grants.gov   Full announcement

Agency contact: National Institutes of Health · grantsinfo@nih.gov · 301-402-2541

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