Selective Precision Targeting (SPoT)
View forecast on Grants.gov →Forecasted — not yet open
- Posted
- June 27, 2025
- Closes
- See announcement
- Program funding
- $1,500,000
- Expected awards
- 5
- Cost sharing
- No
- Instrument
- Cooperative Agreement
- Assistance listing
- 93.350
- Category
- Health
Program funding history
Awards made under Assistance Listing 93.350 across FY2025–FY2027, from public federal spending records.
- FY2025 obligated
- $599.3M
- FY2026 obligated
- $627.8M
- FY2027 (to date) obligated
- $0
- Awards in window
- 772
Top recipients: Vanderbilt University Medical Center, University of Pittsburgh - of the Commonwealth System of Higher Education, Regents of the University of Michigan, Trustees of the University of Pennsylvania, the, The Johns Hopkins University
Source: USAspending.gov · refreshed October 2026 · Program page: awards, recipients and the opportunities under this listing →
Synopsis
The National Center for Advancing Translational Science (NCATS) seeks to advance its mission by establishing a new initiative called Selective Precision Targeting (SPoT) to determine a mechanism for precise and on-target therapeutic drug delivery to specific hard-to-reach locations within the human body using microphysiological systems (MPS). Targeted drug-delivery systems, including engineered nanoparticles, extracellular vesicles or focused ultrasound, are methods for delivering medications to a specific area of the body (organ, tissue, or cell) to increase the concentration of the drug in that area. Hard-to-reach locations in the body include the blood–brain barrier, central nervous system, placenta, retina, or a tumor.
More specifically, the initiative goals are to:
- Optimize specific targeting of nanoparticle therapeutics to the target organ/cell of interest
- Assess biodistribution and off-target effects using a multi-organ microphysiological system
- Provide evidence of functional cargo activity
- Determine optimal route of administration
Grant authorities that allow the National Center for Advancing Translational Science (NCATS) to forecast this opportunity are as follows: 42 U.S. Code § 287a - Cures Acceleration Network.
Who can apply
- Public and State controlled institutions of higher education
- Private institutions of higher education
- For profit organizations other than small businesses
- Small businesses
- Native American tribal organizations (other than Federally recognized tribal governments)
- State governments
- County governments
- Independent school districts
- Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education
- Native American tribal governments (Federally recognized)
- Public housing authorities/Indian housing authorities
How to apply
Applications go through the official government listing. Grants Radar links you straight to the source — applying is free.
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