Notice of Intent to Publish a Funding Opportunity Announcement for Trailblazer Award for New and Early-Stage Investigators (R21 Clinical Trial Optional)
View forecast on Grants.gov →Forecasted — not yet open
- Posted
- June 11, 2025
- Closes
- See announcement
- Cost sharing
- No
- Instrument
- Grant
- Assistance listing
- 93.286
- Category
- Health
Program funding history
Awards made under Assistance Listing 93.286 across FY2024–FY2026, from public federal spending records.
- FY2024 obligated
- $343.8M
- FY2025 obligated
- $339.6M
- FY2026 (to date) obligated
- $228.8M
- Awards in window
- 2,163
Top recipients: The General Hospital Corporation, The Johns Hopkins University, Brigham & Womens Hospital Inc, University of California, Davis, The Leland Stanford Junior University
Source: USAspending.gov · refreshed August 2026
Synopsis
The National Institute of Biomedical Imaging and Bioengineering, with the National Eye Institute, the National Institute on Aging, the National Cancer Institute, and the National Center for Complementary and Integrative Health intend to publish a Notice of Funding Opportunity (NOFO) to solicit applications for the Trailblazer Award. This is an opportunity for NIH-defined New and Early Stage Investigators (https://grants.nih.gov/policy/early-investigators/index.htm) to pursue research programs that integrate engineering and the physical sciences with the life and/or biomedical sciences. A Trailblazer project may be exploratory, developmental, proof of concept, or high-risk high-impact, and may be technology design-directed, discovery-driven, or hypothesis-driven. Applications are not being solicited at this time. Notice is being provided to allow potential applicants sufficient time to develop meaningful collaborations and responsive projects. This NOFO will utilize the R21 activity code. Investigators with expertise and insights into the application of principles and techniques from engineering and quantitative sciences, such as physics, mathematics, chemistry, and computer sciences are encouraged to begin to consider applying for this new NOFO. In addition, collaborative investigations combining expertise in trans-disciplinary research approaches with the potential to open new areas of biomedical investigation will be encouraged and these investigators should also begin considering applying for this application.
Who can apply
- Private institutions of higher education
- Native American tribal governments (Federally recognized)
- Native American tribal organizations (other than Federally recognized tribal governments)
- Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education
- Independent school districts
- State governments
- County governments
- Small businesses
- Public and State controlled institutions of higher education
- For profit organizations other than small businesses
- Public housing authorities/Indian housing authorities
How to apply
Applications go through the official government listing. Grants Radar links you straight to the source — applying is free.
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