Open

Discovery of in vivo Chemical Probes for the Nervous System (R01 Clinical Trial Not Allowed)

Federal funding opportunity PAR-27-081 from National Institutes of Health (Department of Health and Human Services).

Apply on Grants.gov →Application closes March 5, 2027

Posted: May 4, 2026
Closes: March 5, 2027
Cost sharing: No
Instrument: Grant
Assistance listing: 93.866, 93.242, 93.867, 93.279
Category: Health
Archives: May 4, 2027

Program funding history

Awards made under Assistance Listing 93.866 (one of 4 on this opportunity) across FY2025–FY2027, from public federal spending records.

FY2025 obligated: $3.9B
FY2026 obligated: $3.9B
FY2027 (to date) obligated: $0
Awards in window: 10,710

Top recipients: Washington University, the, Regents of the University of Michigan, University of Southern California, The Trustees of Columbia University in the City of New York, Regents of the University of California, San Francisco, the

Source: USAspending.gov · refreshed October 2026 · Program page: awards, recipients and the opportunities under this listing →

Synopsis

The purpose of this Notice of Funding Opportunity (NOFO) is to support investigators who have the interest and capability to join efforts for the discovery of in vivo chemical probes for novel brain targets. It is expected that applicants will have, in hand, the starting compounds (validated hits) for chemical optimization and bioassays for testing new analog compounds. Through this NOFO, NIH wishes to stimulate research in: Discovery and development of novel, small molecules for their potential use in understanding biological processes relevant to the missions of National Institute of Mental Health (NIMH), National Institute on Drug Abuse (NIDA), National Eye Institute (NEI), and/or National Institute on Aging (NIA) andDiscovery and/or validation of novel, biological targets that will inform studies of brain disease mechanisms. Emphasis will be placed on projects that provide new insight into important disease-related biological targets and biological processes.

Who can apply

Native American tribal governments (Federally recognized)
Small businesses
Special district governments
Public housing authorities/Indian housing authorities
For profit organizations other than small businesses
Others (see text field entitled "Additional Information on Eligibility" for clarification)
Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education
Native American tribal organizations (other than Federally recognized tribal governments)
County governments
Independent school districts
State governments
City or township governments
Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education
Private institutions of higher education
Public and State controlled institutions of higher education

Refer to Section III. Eligibility Information in the NOFO for additional information on eligibility. Foreign Organizations/International CollaborationsNon-domestic (non-U.S.) Entities (Foreign Organizations) are eligible to apply. Non-domestic (non-U.S.) components of U.S. Organizations are eligible to apply. Foreign components, as defined in the NIH Grants Policy Statement, are allowed.

How to apply

Applications go through the official government listing. Grants Radar links you straight to the source — applying is free.

View on Grants.gov

Agency contact: National Institutes of Health · [email protected] · 301-402-2541

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