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Discovery of in vivo Chemical Probes for the Nervous System (R01 Clinical Trial Not Allowed)

Federal funding opportunity PAR-27-081 from National Institutes of Health (Department of Health and Human Services).

Apply on Grants.gov →Application closes March 5, 2027

Posted
May 4, 2026
Closes
March 5, 2027
Cost sharing
No
Instrument
Grant
Assistance listing
93.866, 93.242, 93.867, 93.279
Category
Health
Archives
May 4, 2027

Program funding history

Awards made under Assistance Listing 93.866 across FY2024–FY2026, from public federal spending records.

FY2024 obligated
$3.8B
FY2025 obligated
$3.9B
FY2026 (to date) obligated
$1.7B
Awards in window
11,903

Top recipients: Regents of the University of Michigan, Regents of the University of California, San Francisco, the, The Trustees of Columbia University in the City of New York, Washington University, the, University of Southern California

Source: USAspending.gov · refreshed July 2026

Synopsis

The purpose of this Notice of Funding Opportunity (NOFO) is to support investigators who have the interest and capability to join efforts for the discovery of in vivo chemical probes for novel brain targets. It is expected that applicants will have, in hand, the starting compounds (validated hits) for chemical optimization and bioassays for testing new analog compounds.Through this NOFO, NIH wishes to stimulate research in:Discovery and development of novel, small molecules for their potential use in understanding biological processes relevant to the missions of National Institute of Mental Health (NIMH), National Institute on Drug Abuse (NIDA), National Eye Institute (NEI), and/or National Institute on Aging (NIA) andDiscovery and/or validation of novel, biological targets that will inform studies of brain disease mechanisms.Emphasis will be placed on projects that provide new insight into important disease-related biological targets and biological processes.

Who can apply

Refer to Section III. Eligibility Information in the NOFO for additional information on eligibility.Foreign Organizations/International CollaborationsNon-domestic (non-U.S.) Entities (Foreign Organizations) are eligible to apply.Non-domestic (non-U.S.) components of U.S. Organizations are eligible to apply.Foreign components, as defined in the NIH Grants Policy Statement, are allowed.

How to apply

Applications go through the official government listing. Grants Radar links you straight to the source.

View on Grants.gov

Agency contact: National Institutes of Health · NIA-NOFO-Scientific@nih.gov · 301-402-2541

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