Genomic Variant Interactions With Other Variants Or The Environment (UM1 Clinical Trials Not Allowed)
Apply on Grants.gov →Application closes December 14, 2026
- Posted
- October 9, 2026
- Closes
- December 14, 2026
- Award ceiling
- $1,500,000
- Program funding
- $10,000,000
- Expected awards
- 5
- Cost sharing
- No
- Instrument
- Cooperative Agreement
- Assistance listing
- 93.172
- Category
- Health
- Archives
- February 14, 2027
Program funding history
Awards made under Assistance Listing 93.172 across FY2025–FY2027, from public federal spending records.
- FY2025 obligated
- $420.8M
- FY2026 obligated
- $445M
- FY2027 (to date) obligated
- $0
- Awards in window
- 1,087
Top recipients: The Leland Stanford Junior University, The Broad Institute, Inc, University of Washington, University of North Carolina at Chapel Hill, Jackson Laboratory
Source: USAspending.gov · refreshed October 2026 · Program page: awards, recipients and the opportunities under this listing →
Synopsis
The purpose of this Notice of Funding Opportunity (NOFO) is to solicit applications to study the effects of genetic or environmental interactions on genomic variant impact. To accomplish this, interaction centers will first propose a research framework to investigate whether interactions with effects beyond additive are important modifiers of the impact of variants. Centers will apply their framework to experimentally test combinations for interactions and share their data as well as analyses through the Impact of Genomic Variation on Function (IGVF) portal and catalog. Centers will share their method for predicting the most important combinations for future testing. The rationale for this combination of research and resource work is the identification of a structure within the interaction landscape might result in better predictions of the most important interactions to test, leading to more effective variant testing, better understanding of genome-wide association studies (GWAS), and improved polygenic scores. As IGVF Consortium members, centers will work together to ensure all consortium resources are accessible to a wide variety of potential users. Centers are also expected to collaborate with other consortium components to coordinate assays, variants, and cell types, and to develop shared analysis strategies to meet consortium goals.
Who can apply
- City or township governments
- Others (see text field entitled "Additional Information on Eligibility" for clarification)
- State governments
- Special district governments
- Small businesses
- For profit organizations other than small businesses
- Native American tribal organizations (other than Federally recognized tribal governments)
- Independent school districts
- Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education
- County governments
- Public and State controlled institutions of higher education
- Native American tribal governments (Federally recognized)
- Public housing authorities/Indian housing authorities
- Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education
- Private institutions of higher education
Refer to Section III. Eligibility Information in the NOFO for additional information on eligibility. Foreign Organizations/Foreign CollaborationsNon-domestic (non-U.S.) Entities (Foreign Organizations) are eligible to apply. Non-domestic (non-U.S.) components of U.S. Organizations are eligible to apply. Foreign components, as defined in the NIH Grants Policy Statement, are allowed. NIH will no longer issue awards (i.e., new, renewal, or non-competing continuation) to domestic or foreign entities that involve foreign subawards/subcontracts. All NIH-funded research involving foreign subawards/subcontracts must be submitted in response to a NOFO that is specifically designated for funded international collaborations. See NIH Grants Policy Statement 16.8 Collaborative International Research Awards. Applications involving foreign subawards/subcontracts submitted in response to this NOFO will be deemed noncompliant and will not be considered for funding. This policy applies to all monetary international collaborations resulting in foreign subawards/subcontracts, however, it does not preclude unfunded international collaborations or foreign components, funding for foreign consultants, or procurement of unique equipment or supplies from foreign vendors.
How to apply
Applications go through the official government listing. Grants Radar links you straight to the source — applying is free.
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