Systematic Characterization of Genomic Variation to Assess Effects of Individual Variants on Genome Function and Phenotype (UM1 Clinical Trials Not Allowed)
Apply on Grants.gov →Application closes December 14, 2026
- Posted
- October 9, 2026
- Closes
- December 14, 2026
- Award ceiling
- $2,000,000
- Program funding
- $15,000,000
- Expected awards
- 5
- Cost sharing
- No
- Instrument
- Cooperative Agreement
- Assistance listing
- 93.172
- Category
- Health
- Archives
- February 14, 2027
Program funding history
Awards made under Assistance Listing 93.172 across FY2025–FY2027, from public federal spending records.
- FY2025 obligated
- $420.8M
- FY2026 obligated
- $445M
- FY2027 (to date) obligated
- $0
- Awards in window
- 1,087
Top recipients: The Leland Stanford Junior University, The Broad Institute, Inc, University of Washington, University of North Carolina at Chapel Hill, Jackson Laboratory
Source: USAspending.gov · refreshed October 2026 · Program page: awards, recipients and the opportunities under this listing →
Synopsis
The purpose of this Notice of Funding Opportunity (NOFO) is to solicit applications to characterize genomic variation to assess the impact of individual variants on genome function. This will be accomplished by systematically perturbing variants or elements using one or more high-throughput methods; collecting data on the effects of variants in DNA, RNA, or protein-coding elements on molecular, cellular, or organismal phenotypes; and developing robust, reproducible, and portable data processing pipelines. Centers funded through this initiative will become a part of the Impact of Genomic Variation on Function (IGVF) Consortium. As consortium members, centers will work together to ensure all consortium resources are accessible to a wide variety of potential users. Centers are also expected to collaborate with other consortium components to coordinate assays, variants, and cell types, and to develop shared analysis strategies to meet consortium goals.
Who can apply
- Public and State controlled institutions of higher education
- For profit organizations other than small businesses
- Public housing authorities/Indian housing authorities
- Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education
- City or township governments
- Independent school districts
- Private institutions of higher education
- Special district governments
- Small businesses
- Native American tribal governments (Federally recognized)
- Native American tribal organizations (other than Federally recognized tribal governments)
- Others (see text field entitled "Additional Information on Eligibility" for clarification)
- Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education
- State governments
- County governments
Refer to Section III. Eligibility Information in the NOFO for additional information on eligibility. Foreign Organizations/Foreign CollaborationsNon-domestic (non-U.S.) Entities (Foreign Organizations) are eligible to apply. Non-domestic (non-U.S.) components of U.S. Organizations are eligible to apply. Foreign components, as defined in the NIH Grants Policy Statement, are allowed. NIH will no longer issue awards (i.e., new, renewal, or non-competing continuation) to domestic or foreign entities that involve foreign subawards/subcontracts. All NIH-funded research involving foreign subawards/subcontracts must be submitted in response to a NOFO that is specifically designated for funded international collaborations. See NIH Grants Policy Statement 16.8 Collaborative International Research Awards. Applications involving foreign subawards/subcontracts submitted in response to this NOFO will be deemed noncompliant and will not be considered for funding. This policy applies to all monetary international collaborations resulting in foreign subawards/subcontracts, however, it does not preclude unfunded international collaborations or foreign components, funding for foreign consultants, or procurement of unique equipment or supplies from foreign vendors.
How to apply
Applications go through the official government listing. Grants Radar links you straight to the source — applying is free.
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