Archived

Dynamic and Adaptable Infrastructure for Drug Development and Outreach to Aid the Research Community in Advancing Medication Repurposing and Repositioning Efforts for Substance Use Disorders (SUDs) (U54 - Clinical Trials Not Allowed)

Federal funding opportunity RFA-DA-26-020 from National Institutes of Health (Department of Health and Human Services).

Posted: September 24, 2025
Closed: January 28, 2026
Cost sharing: No
Instrument: Cooperative Agreement
Assistance listing: 93.279
Category: Education, Health
Archives: March 5, 2026

Program funding history

Awards made under Assistance Listing 93.279 across FY2025–FY2027, from public federal spending records.

FY2025 obligated: $1.5B
FY2026 obligated: $1.5B
FY2027 (to date) obligated: $0
Awards in window: 4,922

Top recipients: Yale Univ, The Johns Hopkins University, University of California, San Diego, University of Pittsburgh - of the Commonwealth System of Higher Education, Regents of the University of Michigan

Source: USAspending.gov · refreshed October 2026 · Program page: awards, recipients and the opportunities under this listing →

This opportunity is archived. Applications are no longer accepted. Similar grants are listed below, and the free Tuesday digest carries the next ones like it.

Synopsis

This Notice of Funding Opportunity seeks applications to establish and operate a dynamic and adaptable drug development infrastructure to support the research community. The aim is to strengthen and expand the substance use disorder (SUD) drug development pipeline by accelerating the evaluation and validation of repurposed and repositioned drugs. The Center and its team of subject matter experts will provide comprehensive drug development services to academic and biotech researchers at all stages of product development. By supporting various projects that address different SUD indications, the Center will contribute to reducing the burden of SUDs on individuals and communities. The services offered will include assistance in creating Target Product Profiles, Freedom-to-Operate analysis, intellectual property consultations, regulatory guidance, and technical pipeline support. Additionally, the Center will engage in outreach efforts to connect with the research community, solicit proposals, and implement processes to evaluate, select, and advance the projects focused on repurposing and repositioning medications for SUD treatment.

Who can apply

Native American tribal governments (Federally recognized)
County governments
Public housing authorities/Indian housing authorities
Special district governments
Private institutions of higher education
Small businesses
Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education
Public and State controlled institutions of higher education
For profit organizations other than small businesses
Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education
Native American tribal organizations (other than Federally recognized tribal governments)
City or township governments
State governments
Others (see text field entitled "Additional Information on Eligibility" for clarification)
Independent school districts

Other Eligible Applicants include the following: Eligible Agencies of the Federal Government; Faith-based or Community-based Organizations; Indian/Native American Tribal Governments (Other than Federally Recognized); Non-domestic (non-U.S.) Entities (Foreign Organizations); Regional Organizations; U.S. Territory or Possession.

The official record

Grants.gov published the official terms and dates of this opportunity; this page keeps them as they were listed.

View on Grants.gov Full announcement

Agency contact: National Institutes of Health · [email protected] · 301-402-2541

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