Development of Models, New Approach Methodologies, and Biological Materials for Studying Human Health and Diseases (R21 Clinical Trial Not Allowed)
View forecast on Grants.gov →Forecasted — not yet open
- Posted
- September 16, 2026
- Closes
- See announcement
- Award ceiling
- $500,000
- Award floor
- $190,000
- Expected awards
- 15
- Cost sharing
- No
- Instrument
- Grant
- Assistance listing
- 93.351
- Category
- Health
Program funding history
Awards made under Assistance Listing 93.351 across FY2025–FY2027, from public federal spending records.
- FY2025 obligated
- $281.4M
- FY2026 obligated
- $276.6M
- FY2027 (to date) obligated
- $0
- Awards in window
- 894
Top recipients: University of California, Davis, Oregon Health & Science University, University of Washington, Emory University, The Administrators of Tulane Educational Fund
Source: USAspending.gov · refreshed October 2026 · Program page: awards, recipients and the opportunities under this listing →
Synopsis
This notice of funding opportunity (NOFO) encourages innovative research to develop, characterize, improve or preserve research models and model related biological materials, and to develop or improve technologies, including new approach methodologies (NAMs), for studies relevant to human health and diseases. This NOFO also seeks projects aimed at improving the identification and control of factors that could confound or interfere with the use of research models in biomedical research. The proposed project must have broad applicability to multiple NIH Institutes or Centers (ICs) to align with the NIH-wide mission of the Office of Research Infrastructure Programs (ORIP). The proposed studies must include research model(s) or NAM(s) and must explore multiple body systems or multiple categories of diseases affecting multiple body systems. Applications that develop models focused on a specific disease, a narrow area of research, or a single body system, or propose studies primarily relevant to a single NIH IC will be considered not acceptable to this NOFO.
Who can apply
- Native American tribal organizations (other than Federally recognized tribal governments)
- Special district governments
- Public housing authorities/Indian housing authorities
- Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education
- Private institutions of higher education
- Public and State controlled institutions of higher education
- State governments
- County governments
- City or township governments
- Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education
- For profit organizations other than small businesses
- Native American tribal governments (Federally recognized)
- Small businesses
- Independent school districts
- Others (see text field entitled "Additional Information on Eligibility" for clarification)
Other Eligible ApplicantsIndian/Native American Tribal Governments (Other than Federally Recognized);Eligible Agencies of the Federal Government;U.S. Territory or Possession;Faith-based or Community-based Organizations;Regional Organizations;Non-domestic (non-U.S.) Entities (Foreign Institutions).
How to apply
Applications go through the official government listing. Grants Radar links you straight to the source — applying is free.
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