Resource-Related Research Projects for Development of Models and Related Materials for Studying Human Health and Diseases (R24 Clinical Trials Not Allowed)

Federal funding opportunity RFA-OD-25-010 from National Institutes of Health (Department of Health and Human Services).

Apply on Grants.gov →Application closes September 28, 2028

Posted: December 5, 2025
Closes: September 28, 2028
Program funding: $5,000,000
Expected awards: 6
Cost sharing: No
Instrument: Grant
Assistance listing: 93.351
Category: Health
Archives: November 2, 2028

Program funding history

Awards made under Assistance Listing 93.351 across FY2024–FY2026, from public federal spending records.

FY2024 obligated: $279M
FY2025 obligated: $281.4M
FY2026 (to date) obligated: $138.1M
Awards in window: 1,100

Top recipients: University of California, Davis, Oregon Health & Science University, University of Washington, Emory University, Texas Biomedical Research Institute

Source: USAspending.gov · refreshed July 2026

Synopsis

The Office of Research Infrastructure Programs (ORIP) encourages grant applications aimed at developing, characterizing, or improving research models of human health and diseases; developing biology based new approach methodologies (NAMs) applicable to human health and diseases; or improving access to information about or generated from the use of models of human disease. The models, including NAMs, and related biological materials developed must be broadly applicable to the scientific interests of two or more NIH Institutes or Centers (ICs) and must evaluate diseases and processes that impact multiple organ systems in order to align with the ORIP"s NIH-wide mission and programs. Applications must describe the need for and the potential impact of the proposed resources on the research community across a range of scientific disciplines supported by multiple NIH ICs. Applications to develop models that relate strictly to a specific disease or a select area of research or that do not have a broad impact on the NIH-wide research community will not be accepted. Projects that predominantly address the research interests of one NIH IC but are only peripherally related to the research interests of other ICs will also not be accepted, if submitted in response to this notice of funding opportunity (NOFO).

Who can apply

Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education
County governments
Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education
For profit organizations other than small businesses
State governments
Native American tribal governments (Federally recognized)
Private institutions of higher education
Small businesses
City or township governments
Public and State controlled institutions of higher education
Others (see text field entitled "Additional Information on Eligibility" for clarification)

Refer to Section III. Eligibility Information of the NOFO for additional information on eligibility.Foreign Organizations/Foreign CollaborationsNon-domestic (non-U.S.) Entities (Foreign Organizations) are not eligible to apply.Non-domestic (non-U.S.) components of U.S. Organizations are not eligible to apply.Foreign components, as defined in the NIH Grants Policy Statement, are not allowed.

How to apply

Applications go through the official government listing. Grants Radar links you straight to the source.

View on Grants.gov

Agency contact: National Institutes of Health · ORIPDCM@mail.nih.gov · 301-402-2541

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