Open

Causal Hypotheses on the Oral-Systemic Health Impacts of Human Behaviors among People with Chronic Conditions (U01 Clinical Trial Not Allowed)

Federal funding opportunity PAR-27-057 from National Institutes of Health (Department of Health and Human Services).

Apply on Grants.gov →Application closes July 5, 2029

Posted: June 4, 2026
Closes: July 5, 2029
Award ceiling: $500,000
Cost sharing: No
Instrument: Cooperative Agreement
Assistance listing: 93.121
Category: Health
Archives: September 3, 2029

Program funding history

Awards made under Assistance Listing 93.121 across FY2025–FY2027, from public federal spending records.

FY2025 obligated: $378.9M
FY2026 obligated: $380.8M
FY2027 (to date) obligated: $0
Awards in window: 2,170

Top recipients: Regents of the University of California, San Francisco, the, Regents of the University of Michigan, University of Pittsburgh - of the Commonwealth System of Higher Education, University of Florida, University of Southern California

Source: USAspending.gov · refreshed October 2026 · Program page: awards, recipients and the opportunities under this listing →

Synopsis

This Notice of Funding Opportunity (NOFO) invites applications for innovative research on the factors that cause human behaviors and the oral-systemic health impacts of those behaviors to enhance health, lengthen life, and reduce illness and disability among people with chronic conditions. Causal hypotheses may include biological, biopsychosocial, congenital, environmental, interpersonal, neurological, psychological, and comorbidity factors that individually, sequentially, or in combination trigger human behaviors and oral-systemic health outcomes, with impacts that may be direct or traceably distal. Applications that propose projects to develop or refine causal hypotheses also are encouraged.

Who can apply

Others (see text field entitled "Additional Information on Eligibility" for clarification)
Private institutions of higher education
Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education
Special district governments
State governments
Native American tribal organizations (other than Federally recognized tribal governments)
Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education
City or township governments
County governments
Independent school districts
Public and State controlled institutions of higher education
Native American tribal governments (Federally recognized)
For profit organizations other than small businesses
Public housing authorities/Indian housing authorities
Small businesses

Refer to Section III. Eligibility Information in the NOFO for additional information on eligibility. Foreign Organizations/International Collaborations: Non-domestic (non-U.S.) Entities (Foreign Organizations) are not eligible to apply. Non-domestic (non-U.S.) components of U.S. Organizations are not eligible to apply. Foreign components, as defined in the NIH Grants Policy Statement, are not allowed.

How to apply

Applications go through the official government listing. Grants Radar links you straight to the source — applying is free.

View on Grants.gov

Agency contact: National Institutes of Health · [email protected] · 301-402-2541

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