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Causal Hypotheses on the Oral-Systemic Health Impacts of Human Behaviors among People with Chronic Conditions (U01 Clinical Trial Not Allowed)

Federal funding opportunity PAR-27-057 from National Institutes of Health (Department of Health and Human Services).

Apply on Grants.gov →Application closes July 5, 2029

Posted
June 4, 2026
Closes
July 5, 2029
Award ceiling
$500,000
Cost sharing
No
Instrument
Cooperative Agreement
Assistance listing
93.121
Category
Health
Archives
September 3, 2029

Program funding history

Awards made under Assistance Listing 93.121 across FY2024–FY2026, from public federal spending records.

FY2024 obligated
$379.1M
FY2025 obligated
$378.9M
FY2026 (to date) obligated
$179.8M
Awards in window
2,319

Top recipients: Regents of the University of Michigan, Regents of the University of California, San Francisco, the, University of Southern California, University of Pittsburgh - of the Commonwealth System of Higher Education, Trustees of the University of Pennsylvania, the

Source: USAspending.gov · refreshed July 2026

Synopsis

This Notice of Funding Opportunity (NOFO) invites applications for innovative research on the factors that cause human behaviors and the oral-systemic health impacts of those behaviors to enhance health, lengthen life, and reduce illness and disability among people with chronic conditions. Causal hypotheses may include biological, biopsychosocial, congenital, environmental, interpersonal, neurological, psychological, and comorbidity factors that individually, sequentially, or in combination trigger human behaviors and oral-systemic health outcomes, with impacts that may be direct or traceably distal. Applications that propose projects to develop or refine causal hypotheses also are encouraged.

Who can apply

Refer to Section III. Eligibility Information in the NOFO for additional information on eligibility.Foreign Organizations/International Collaborations:Non-domestic (non-U.S.) Entities (Foreign Organizations) are not eligible to apply.Non-domestic (non-U.S.) components of U.S. Organizations are not eligible to apply.Foreign components, as defined in the NIH Grants Policy Statement, are not allowed.

How to apply

Applications go through the official government listing. Grants Radar links you straight to the source.

View on Grants.gov

Agency contact: National Institutes of Health · deeranotifications@nidcr.nih.gov · 301-402-2541

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