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Pilot Projects Investigating Understudied Proteins Associated with Rare Diseases (R03 Clinical Trial Not Allowed)

Federal funding opportunity PAR-25-122 from National Institutes of Health (Department of Health and Human Services).

Apply on Grants.gov →Application closes November 16, 2027

Posted
October 28, 2024
Closes
November 16, 2027
Award ceiling
$100,000
Cost sharing
No
Instrument
Grant
Assistance listing
93.121, 93.853, 93.173, 93.350, 93.855, 93.242
Category
Health
Archives
December 22, 2027

Program funding history

Awards made under Assistance Listing 93.121 across FY2024–FY2026, from public federal spending records.

FY2024 obligated
$379.1M
FY2025 obligated
$378.9M
FY2026 (to date) obligated
$179.8M
Awards in window
2,319

Top recipients: Regents of the University of Michigan, Regents of the University of California, San Francisco, the, University of Southern California, University of Pittsburgh - of the Commonwealth System of Higher Education, Trustees of the University of Pennsylvania, the

Source: USAspending.gov · refreshed July 2026

Synopsis

The purpose of this notice of funding opportunity (NOFO) is to solicit applications for pilot projects to elucidate a role for understudied proteins in rare disease. Awards will support generation of preliminary data and/or tools around eligible understudied protein(s). A list of eligible proteins is provided and are members of druggable protein families that have a known association with a rare disease. This NOFO is intended to jumpstart research on understudied proteins that are associated with rare diseases and provide applicants with sufficient funding to perform basic biochemical and/or biological work to further the characterization of understudied proteins within the context of rare disease.

Who can apply

Other Eligible Applicants include the following: Alaska Native and Native Hawaiian Serving Institutions; Asian American Native American Pacific Islander Serving Institutions (AANAPISISs); Eligible Agencies of the Federal Government; Faith-based or Community-based Organizations; Hispanic-serving Institutions; Historically Black Colleges and Universities (HBCUs); Indian/Native American Tribal Governments (Other than Federally Recognized); Non-domestic (non-U.S.) Entities (Foreign Organizations); Regional Organizations; Tribally Controlled Colleges and Universities (TCCUs) ; U.S. Territory or Possession; Non-domestic (non-U.S.) Entities (Foreign Organizations) are not eligible to apply. Non-domestic (non-U.S.) components of U.S. Organizations are not eligible to apply. Foreign components, as defined in the NIH Grants Policy Statement, are allowed.

How to apply

Applications go through the official government listing. Grants Radar links you straight to the source.

View on Grants.gov   Full announcement

Agency contact: National Institutes of Health · grantsinfo@nih.gov · 301-402-2541

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