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Pilot Projects Investigating Understudied Proteins Associated with Rare Diseases (R03 Clinical Trial Not Allowed)

Federal funding opportunity PAR-25-122 from National Institutes of Health (Department of Health and Human Services).

Apply on Grants.gov →Application closes November 16, 2027

Posted: October 28, 2024
Closes: November 16, 2027
Award ceiling: $100,000
Cost sharing: No
Instrument: Grant
Assistance listing: 93.121, 93.853, 93.173, 93.350, 93.855, 93.242
Category: Health
Archives: December 22, 2027

Program funding history

Awards made under Assistance Listing 93.121 across FY2024–FY2026, from public federal spending records.

FY2024 obligated: $379.1M
FY2025 obligated: $378.9M
FY2026 (to date) obligated: $266.9M
Awards in window: 2,392

Top recipients: Regents of the University of Michigan, Regents of the University of California, San Francisco, the, University of Pittsburgh - of the Commonwealth System of Higher Education, University of Southern California, Trustees of the University of Pennsylvania, the

Source: USAspending.gov · refreshed August 2026

Synopsis

The purpose of this notice of funding opportunity (NOFO) is to solicit applications for pilot projects to elucidate a role for understudied proteins in rare disease. Awards will support generation of preliminary data and/or tools around eligible understudied protein(s). A list of eligible proteins is provided and are members of druggable protein families that have a known association with a rare disease. This NOFO is intended to jumpstart research on understudied proteins that are associated with rare diseases and provide applicants with sufficient funding to perform basic biochemical and/or biological work to further the characterization of understudied proteins within the context of rare disease.

Who can apply

County governments
Public and State controlled institutions of higher education
Private institutions of higher education
Others (see text field entitled "Additional Information on Eligibility" for clarification)
Native American tribal organizations (other than Federally recognized tribal governments)
Native American tribal governments (Federally recognized)
City or township governments
Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education
For profit organizations other than small businesses
State governments
Public housing authorities/Indian housing authorities
Special district governments
Independent school districts
Small businesses
Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education

Other Eligible Applicants include the following: Alaska Native and Native Hawaiian Serving Institutions; Asian American Native American Pacific Islander Serving Institutions (AANAPISISs); Eligible Agencies of the Federal Government; Faith-based or Community-based Organizations; Hispanic-serving Institutions; Historically Black Colleges and Universities (HBCUs); Indian/Native American Tribal Governments (Other than Federally Recognized); Non-domestic (non-U.S.) Entities (Foreign Organizations); Regional Organizations; Tribally Controlled Colleges and Universities (TCCUs) ; U.S. Territory or Possession; Non-domestic (non-U.S.) Entities (Foreign Organizations) are not eligible to apply. Non-domestic (non-U.S.) components of U.S. Organizations are not eligible to apply. Foreign components, as defined in the NIH Grants Policy Statement, are allowed.

How to apply

Applications go through the official government listing. Grants Radar links you straight to the source — applying is free.

View on Grants.gov Full announcement

Agency contact: National Institutes of Health · [email protected] · 301-402-2541

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