NIH Exploratory/Developmental Research Grant Program (Parent R21 Clinical Trial Required)
- Posted
- May 7, 2020
- Closed
- January 7, 2025
- Cost sharing
- No
- Instrument
- Grant
- Assistance listing
- 93.173, 93.172, 93.279, 93.855, 93.242, 93.273, 93.867, 93.113, 93.866, 93.361, 93.846
- Category
- Education, Environment, Health
- Archives
- February 6, 2025
Program funding history
Awards made under Assistance Listing 93.173 (one of 11 on this opportunity) across FY2025–FY2027, from public federal spending records.
- FY2025 obligated
- $416.1M
- FY2026 obligated
- $414.8M
- FY2027 (to date) obligated
- $0
- Awards in window
- 2,058
Top recipients: The Johns Hopkins University, Massachusetts Eye and Ear Infirmary, University of Pittsburgh - of the Commonwealth System of Higher Education, New York University, The Leland Stanford Junior University
Source: USAspending.gov · refreshed October 2026 · Program page: awards, recipients and the opportunities under this listing →
Synopsis
The NIH Exploratory/Developmental Grant supports exploratory and developmental research projects by providing support for the early and conceptual stages of these projects. These studies may involve considerable risk but may lead to a breakthrough in a particular area, or to the development of novel techniques, agents, methodologies, models, or applications that could have a major impact on a field of biomedical, behavioral, or clinical research. This Parent Funding Opportunity Announcement requires that at least 1 clinical trial be proposed. The proposed project must be related to the programmatic interests of one or more of the participating NIH Institutes and Centers (ICs) based on their scientific missions. Applicants should note that some ICs (see Related Notices) only accept applications proposing mechanistic studies that meet NIH's definition of a clinical trial through this funding opportunity announcement.
Who can apply
- Native American tribal organizations (other than Federally recognized tribal governments)
- Special district governments
- Native American tribal governments (Federally recognized)
- State governments
- For profit organizations other than small businesses
- Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education
- Small businesses
- City or township governments
- Public housing authorities/Indian housing authorities
- Others (see text field entitled "Additional Information on Eligibility" for clarification)
- Private institutions of higher education
- Public and State controlled institutions of higher education
- Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education
- County governments
- Independent school districts
Other Eligible Applicants include the following: Alaska Native and Native Hawaiian Serving Institutions; Asian American Native American Pacific Islander Serving Institutions (AANAPISISs); Eligible Agencies of the Federal Government; Faith-based or Community-based Organizations; Hispanic-serving Institutions; Historically Black Colleges and Universities (HBCUs); Indian/Native American Tribal Governments (Other than Federally Recognized); Non-domestic (non-U.S.) Entities (Foreign Organizations); Regional Organizations; Tribally Controlled Colleges and Universities (TCCUs) ; U.S. Territory or Possession.
The official record
Grants.gov published the official terms and dates of this opportunity; this page keeps them as they were listed.
View on Grants.gov Full announcement
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