HEAL Initiative: Research to Increase Implementation of Substance Use Preventive Services (R01 Clinical Trial Optional)
- Posted
- September 22, 2023
- Closed
- May 23, 2025
- Cost sharing
- No
- Instrument
- Grant
- Assistance listing
- 93.279, 93.213, 93.866
- Archives
- June 22, 2025
Program funding history
Awards made under Assistance Listing 93.279 (one of 3 on this opportunity) across FY2025–FY2027, from public federal spending records.
- FY2025 obligated
- $1.5B
- FY2026 obligated
- $1.5B
- FY2027 (to date) obligated
- $0
- Awards in window
- 4,922
Top recipients: Yale Univ, The Johns Hopkins University, University of California, San Diego, University of Pittsburgh - of the Commonwealth System of Higher Education, Regents of the University of Michigan
Source: USAspending.gov · refreshed October 2026 · Program page: awards, recipients and the opportunities under this listing →
Synopsis
The importance of prevention in combatting the opioid crisis is clear identifying and implementing effective strategies to prevent the onset of opioid misuse and use disorder and reducing the need to treat disorders yields positive individual, societal, and financial benefits. In 2020, 9.5 million people aged 12 or older misused opioids in the past year (NSDUH, 2021), suggesting that there are millions of people whose trajectories could have been changed, had they been exposed to an effective prevention strategy. Currently funded HEAL studies are testing whether existing programs shown to prevent or treat non-opioid substance use disorders might generalize to opioids. However, there remain many gaps in knowledge about how to deploy prevention services. Often effective strategies are not adopted, implemented, or scaled-up, limiting their reach and impact. There is a critical need for research to develop innovative strategies to implement and sustain prevention services that are affordable, practical, sustainable, and designed in partnership with end-users. To address these gaps, we propose an RFA with multiple receipt dates calling for investigator-initiated research that will address priorities in the implementation and sustainability of prevention services, and the creation of a prevention infrastructure.
Who can apply
- Small businesses
- Private institutions of higher education
- Independent school districts
- County governments
- Native American tribal organizations (other than Federally recognized tribal governments)
- Special district governments
- State governments
- Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education
- Public housing authorities/Indian housing authorities
- For profit organizations other than small businesses
- City or township governments
- Public and State controlled institutions of higher education
- Others (see text field entitled "Additional Information on Eligibility" for clarification)
- Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education
- Native American tribal governments (Federally recognized)
Other Eligible Applicants include the following: Alaska Native and Native Hawaiian Serving Institutions; Asian American Native American Pacific Islander Serving Institutions (AANAPISISs); Eligible Agencies of the Federal Government; Faith-based or Community-based Organizations; Hispanic-serving Institutions; Historically Black Colleges and Universities (HBCUs); Indian/Native American Tribal Governments (Other than Federally Recognized); Non-domestic (non-U.S.) Entities (Foreign Organizations); Regional Organizations; Tribally Controlled Colleges and Universities (TCCUs) ; U.S. Territory or Possession; Non-domestic (non-U.S.) Entities (Foreign Institutions) are not eligible to apply. Non-domestic (non-U.S.) components of U.S. Organizations are not eligible to apply. Foreign components, as defined in the NIH Grants Policy Statement, are allowed.
The official record
Grants.gov published the official terms and dates of this opportunity; this page keeps them as they were listed.
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