Mechanisms Underlying Olfactory Dysfunction in Aging and Alzheimer’s Disease and Alzheimer’s Disease-Related Dementias
Federal funding opportunity RFA-AG-26-021 from National Institutes of Health.
View forecast on Grants.gov →Forecasted — not yet open
- Posted
- November 20, 2025
- Closes
- See announcement
- Cost sharing
- No
- Instrument
- Grant
- Assistance listing
- 93.866
- Category
- Health
Program funding history
Awards made under Assistance Listing 93.866 across FY2024–FY2026, from public federal spending records.
- FY2024 obligated
- $3.8B
- FY2025 obligated
- $3.9B
- FY2026 (to date) obligated
- $1.7B
- Awards in window
- 11,903
Top recipients: Regents of the University of Michigan, Regents of the University of California, San Francisco, the, The Trustees of Columbia University in the City of New York, Washington University, the, University of Southern California
Source: USAspending.gov · refreshed July 2026
Synopsis
The National Institute on Aging (NIA), with the National Institute on Deafness and Other Communication Disorders (NIDCD), intends to publish a Notice of Funding Opportunity (NOFO) to solicit applications that investigate the mechanisms underlying the association between olfactory decline and aging or Alzheimer's disease (AD) and AD-related dementias (ADRD). Understanding these mechanisms may help inform the potential use of olfactory dysfunction with age as an indicator of various health outcomes in older adults (e.g. physical function) and as a predictor of AD/ADRD risk. Identifying circuit-level olfactory changes may also uncover novel targets for developing disease-modifying therapeutic strategies. Studies may include older adults and/or animal models and may employ a variety of approaches, including cellular, molecular, imaging, physiological, omics and new approach methodologies (NAMs) to address the research gaps.
Applications are not being solicited at this time. Notice is being provided to allow potential applicants sufficient time to develop meaningful collaborations and responsive projects. This NOFO intends to utilize the R01 activity code. Investigators with expertise and insights into this area of aging research are encouraged to begin to consider applying for this new NOFO.
Who can apply
- Native American tribal organizations (other than Federally recognized tribal governments)
- Private institutions of higher education
- Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education
- For profit organizations other than small businesses
- Small businesses
- Public and State controlled institutions of higher education
- Native American tribal governments (Federally recognized)
- Public housing authorities/Indian housing authorities
- Others (see text field entitled "Additional Information on Eligibility" for clarification)
- Independent school districts
- Special district governments
- Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education
- County governments
- City or township governments
- State governments
Other Eligible ApplicantsIndian/Native American Tribal Governments (Other than Federally Recognized);Eligible Agencies of the Federal Government;U.S. Territory or Possession;Faith-based or Community-based Organizations;Regional Organizations.
How to apply
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