Archived

The Impact of Stressors on the Biological Mechanisms of Aging and Other Aging-Associated Outcomes in Experimental Model Systems (R61/R33 Clinical Trial Not allowed)

Federal funding opportunity RFA-AG-25-019 from National Institutes of Health (Department of Health and Human Services).

Posted: August 27, 2024
Closed: November 7, 2024
Cost sharing: No
Instrument: Grant
Assistance listing: 93.866
Category: Health
Archives: December 13, 2024

Program funding history

Awards made under Assistance Listing 93.866 across FY2025–FY2027, from public federal spending records.

FY2025 obligated: $3.9B
FY2026 obligated: $3.9B
FY2027 (to date) obligated: $0
Awards in window: 10,710

Top recipients: Washington University, the, Regents of the University of Michigan, University of Southern California, The Trustees of Columbia University in the City of New York, Regents of the University of California, San Francisco, the

Source: USAspending.gov · refreshed October 2026 · Program page: awards, recipients and the opportunities under this listing →

This opportunity is archived. Applications are no longer accepted. Similar grants are listed below, and the free Tuesday digest carries the next ones like it.

Synopsis

Stress is a natural and universal part of life. However, studies that use model systems to investigate the biological mechanisms underlying the aging process (i.e., the hallmarks of aging) and interventions to retard it do not usually integrate exposures to stressors, which limits the translatability of their findings. The overarching objective of this notice of funding opportunity (NOFO) is to invite applications proposing research that incorporates exposures to a stressor(s) during the post-development period (adulthood) into studies of aging processes. Research proposed in the initial, exploratory (R61) phase will seek to determine whether exposure to a stressor(s) (e.g., physical, social, and/or environmental stressors of well-defined duration, intensity, and timing) during adulthood result in measurable changes in one or more of the hallmarks of aging. The second, developmental (R33) phase will then expand upon findings yielded in the R61 phase to determine the impacts of the stressor(s) on lifespan, healthspan, resilience, and/or interactions with other input variables such as genotype, diet, interventions, etc. Applicants can propose to employ in vitro systems; laboratory animals; or well-characterized wild, captive, free-ranging, or domesticated animal populations. Funded projects will receive up to two years of R61 support and may also receive up to three years of R33 support (contingent upon NIAs determination of the success in achieving R61 milestones, NIA priorities, and availability of funds).

Who can apply

Public and State controlled institutions of higher education
Public housing authorities/Indian housing authorities
Native American tribal organizations (other than Federally recognized tribal governments)
Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education
Independent school districts
State governments
Private institutions of higher education
City or township governments
Special district governments
Native American tribal governments (Federally recognized)
County governments
For profit organizations other than small businesses
Small businesses
Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education
Others (see text field entitled "Additional Information on Eligibility" for clarification)

Other Eligible Applicants include the following: Alaska Native and Native Hawaiian Serving Institutions; Asian American Native American Pacific Islander Serving Institutions (AANAPISISs); Eligible Agencies of the Federal Government; Faith-based or Community-based Organizations; Hispanic-serving Institutions; Historically Black Colleges and Universities (HBCUs); Indian/Native American Tribal Governments (Other than Federally Recognized); Non-domestic (non-U.S.) Entities (Foreign Organizations); Regional Organizations; Tribally Controlled Colleges and Universities (TCCUs) ; U.S. Territory or Possession.

The official record

Grants.gov published the official terms and dates of this opportunity; this page keeps them as they were listed.

View on Grants.gov Full announcement

Agency contact: National Institutes of Health · [email protected] · 301-402-2541

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