Open

Expanding the Target Landscape by Drugging the Undruggable (R21 Clinical Trial Not Allowed)

Federal funding opportunity PAR-25-442 from National Institutes of Health (Department of Health and Human Services).

Apply on Grants.gov →Application closes February 17, 2028

Posted: June 17, 2025
Closes: February 17, 2028
Cost sharing: No
Instrument: Grant
Assistance listing: 93.350, 93.121, 93.867, 93.855, 93.865, 93.242
Category: Health
Archives: March 24, 2028

Program funding history

Awards made under Assistance Listing 93.350 across FY2024–FY2026, from public federal spending records.

FY2024 obligated: $588.2M
FY2025 obligated: $599.3M
FY2026 (to date) obligated: $503.7M
Awards in window: 932

Top recipients: Vanderbilt University Medical Center, University of Pittsburgh - of the Commonwealth System of Higher Education, Regents of the University of Michigan, Trustees of the University of Pennsylvania, the, Icahn School of Medicine at Mount Sinai

Source: USAspending.gov · refreshed August 2026

Synopsis

The purpose of this Notice of Funding Opportunity (NOFO) is to solicit applications for exploratory and early-stage projects that focus on undruggable target classes within intractable human disease. Applicants will identify a human disease relevant undruggable target class and develop a method or agent that is selective for one or more targets within that target class. This NOFO is intended to jumpstart research that demonstrates innovative strategies to modulate targets that cannot be addressed by established therapeutic types, furthering the development of methods and/or agents selective for undruggable target classes.

Who can apply

Native American tribal governments (Federally recognized)
Private institutions of higher education
Native American tribal organizations (other than Federally recognized tribal governments)
Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education
State governments
Small businesses
For profit organizations other than small businesses
County governments
Independent school districts
Public and State controlled institutions of higher education
Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education
Others (see text field entitled "Additional Information on Eligibility" for clarification)
Public housing authorities/Indian housing authorities
City or township governments
Special district governments

Other Eligible Applicants include the following: Alaska Native and Native Hawaiian Serving Institutions; Asian American Native American Pacific Islander Serving Institutions (AANAPISISs); Eligible Agencies of the Federal Government; Faith-based or Community-based Organizations; Hispanic-serving Institutions; Historically Black Colleges and Universities (HBCUs); Indian/Native American Tribal Governments (Other than Federally Recognized); Regional Organizations; Tribally Controlled Colleges and Universities (TCCUs) ; U.S. Territory or Possession; Non-domestic (non-U.S.) Entities (Foreign Organizations) are not eligible to apply.Non-domestic (non-U.S.) components of U.S. Organizations are not eligible to apply.Foreign components, as defined in the NIH Grants Policy Statement, are not allowed.

How to apply

Applications go through the official government listing. Grants Radar links you straight to the source — applying is free.

View on Grants.gov Full announcement

Agency contact: National Institutes of Health · [email protected] · 301-402-2541

New to federal funding? How to read an announcement · Who can apply · How grants work

Get grants like this every Tuesday — free

One email a week: the biggest new federal grants and what’s closing soon — the same list for everyone. Unsubscribe in one click.

The free edition carries one clearly labeled sponsor slot. No spam, ever. Privacy

Similar grants

Feasibility Clinical Trials of Mind and Body Interventions for NCCIH High Priority Research Topics (R34 Clinical Trial Required)
PAR-25-274 · National Institutes of Health · closes November 17, 2026
Investigator Initiated Clinical Trials of Complementary and Integrative Interventions Delivered Remotely or via mHealth (R01 Clinical Trial Required)
PAR-25-268 · National Institutes of Health · closes November 17, 2026
Limited Competition: Small Grant Program for the NCATS Clinical and Translational Science Award (CTSA) Program (R03 Clinical Trial Optional)
PAR-25-155 · National Institutes of Health · closes October 19, 2026
Dissemination and Implementation Research in Health (R01 Clinical Trial Optional)
PAR-25-144 · National Institutes of Health · closes January 7, 2028
Dissemination and Implementation Research in Health (R21 Clinical Trial Optional)
PAR-25-143 · National Institutes of Health · closes January 7, 2028
Dissemination and Implementation Research in Health (R03 Clinical Trial Not Allowed)
PAR-25-233 · National Institutes of Health · closes January 7, 2028

Same-day alerts, matched to you

The free digest is weekly — the same list for everyone. Members get an alert the day a matching federal grant posts: we read every new Grants.gov posting and score it, personalized to your organization. Free for 30 days, then $19/mo founding rate locked for life — the rate holds while your subscription stays active (Terms). Card required, cancel any time before day 31.

See pricing