NCCIH Natural Product Early Phase Clinical Trial Phased Innovation Award (R61/R33 Clinical Trial Required)

Federal funding opportunity PAR-25-269 from National Institutes of Health (Department of Health and Human Services).

Apply on Grants.gov →Application closes November 13, 2026

Posted: December 2, 2024
Closes: November 13, 2026
Award ceiling: $350,000
Program funding: $350,000
Cost sharing: No
Instrument: Grant
Assistance listing: 93.213
Category: Health
Archives: December 19, 2026

Program funding history

Awards made under Assistance Listing 93.213 across FY2024–FY2026, from public federal spending records.

FY2024 obligated: $118.3M
FY2025 obligated: $115.4M
FY2026 (to date) obligated: $38.7M
Awards in window: 683

Top recipients: University of California, San Diego, Yale Univ, The General Hospital Corporation, Regents of the University of California, San Francisco, the, The Spaulding Rehabilitation Hospital Corporation

Source: USAspending.gov · refreshed July 2026

Synopsis

This Notice of Funding Opportunity (NOFO) encourages applications for investigator-initiated, early phase, clinical trials of natural products (i.e., botanicals, probiotics, and products marketed as dietary supplements), which have a strong scientific premise to justify further clinical testing. For this NOFO, natural products include promising nutritional regimens that standardize the amount of a specific naturally occurring nutritional compound (e.g., omega-3 fatty acids, anthocyanidins, or polyphenols) and have compelling preliminary evidence. Under this NOFO, trials must be designed so that results, whether positive or negative, will provide information of high scientific utility and will support decisions about further development or testing of the natural product. This NOFO will provide up to three years (R61 phase) of support for milestone-driven testing of pharmacokinetics, bioavailability, and assessment of the natural products effect (i.e., measure of mechanism of action) when used by humans on a specified target measure. If milestones in the R61 phase are achieved, up to 3 years of additional support (R33 phase) may be awarded to replicate the impact of the natural product on target engagement(s) when used by humans and assess whether there is an association between the degree of the impact on the target engagement and clinical outcomes in a participant population. Applications are encouraged to design R33 studies to determine how to optimize the impact of the natural product on the target engagement by optimizing the delivery of the natural product through examination of different doses or formulations. In addition, applications can be designed to combine the natural product with another treatment approach that is known to impact the same target engagement measure; or study the impact of the natural product in a population that is more responsive,

Who can apply

Native American tribal organizations (other than Federally recognized tribal governments)
For profit organizations other than small businesses
Small businesses
Private institutions of higher education
Special district governments
Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education
Independent school districts
Public and State controlled institutions of higher education
Native American tribal governments (Federally recognized)
County governments
City or township governments
Others (see text field entitled "Additional Information on Eligibility" for clarification)
Public housing authorities/Indian housing authorities
Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education
State governments

Other Eligible Applicants include the following: Alaska Native and Native Hawaiian Serving Institutions; Asian American Native American Pacific Islander Serving Institutions (AANAPISISs); Eligible Agencies of the Federal Government; Faith-based or Community-based Organizations; Hispanic-serving Institutions; Historically Black Colleges and Universities (HBCUs); Indian/Native American Tribal Governments (Other than Federally Recognized); Non-domestic (non-U.S.) Entities (Foreign Organizations); Regional Organizations; Tribally Controlled Colleges and Universities (TCCUs) ; U.S. Territory or Possession; Non-domestic (non-U.S.) Entities (Foreign Organizations) are not eligible to apply. Non-domestic (non-U.S.) components of U.S. Organizations are not eligible to apply.

How to apply

Applications go through the official government listing. Grants Radar links you straight to the source.

View on Grants.gov Full announcement

Agency contact: National Institutes of Health · grantsinfo@nih.gov · 301-402-2541

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