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Clinical Characterization of Cancer Therapy-induced Adverse Sequelae and Mechanism-based Interventional Strategies (R01 Clinical Trial Optional)

Federal funding opportunity PAR-25-145 from National Institutes of Health (Department of Health and Human Services).

Apply on Grants.gov →Application closes January 7, 2028

Posted: November 6, 2024
Closes: January 7, 2028
Cost sharing: No
Instrument: Grant
Assistance listing: 93.393
Category: Education, Health
Archives: February 12, 2028

Program funding history

Awards made under Assistance Listing 93.393 across FY2024–FY2026, from public federal spending records.

FY2024 obligated: $730.8M
FY2025 obligated: $803.1M
FY2026 (to date) obligated: $471.3M
Awards in window: 2,980

Top recipients: The Univeristy of Texas M.d. Anderson Cancer Center, Dana-farber Cancer Institute, Inc., Sloan-kettering Institute for Cancer Research, University of North Carolina at Chapel Hill, The Trustees of Columbia University in the City of New York

Source: USAspending.gov · refreshed August 2026

Synopsis

The purpose of this Funding Opportunity Announcement (FOA) is to support collaborative research projects designed to address adverse sequelae of cancer therapies that persist and become chronic comorbidities or develop as delayed posttreatment effects. This FOA supports basic, translational, and clinical research projects that seek to identify the mechanisms of therapy-induced adverse sequelae, clinically characterize the adverse sequelae, or translate the mechanistic understanding into therapeutic approaches to prevent or minimize the development of long-term sequelae. Research projects should focus on mechanistic studies with translational endpoints and longitudinal clinical phenotyping to identify and validate clinical endpoints (biomarkers, imaging, patient-reported outcomes, or combined elements) for future use in clinical trials that will evaluate the efficacy of interventions designed to prevent or reduce specific adverse sequelae.

Who can apply

Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education
Others (see text field entitled "Additional Information on Eligibility" for clarification)
Special district governments
City or township governments
Independent school districts
Native American tribal governments (Federally recognized)
Private institutions of higher education
State governments
Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education
For profit organizations other than small businesses
County governments
Public housing authorities/Indian housing authorities
Small businesses
Public and State controlled institutions of higher education
Native American tribal organizations (other than Federally recognized tribal governments)

Other Eligible Applicants include the following: Alaska Native and Native Hawaiian Serving Institutions; Asian American Native American Pacific Islander Serving Institutions (AANAPISISs); Eligible Agencies of the Federal Government; Faith-based or Community-based Organizations; Hispanic-serving Institutions; Historically Black Colleges and Universities (HBCUs); Indian/Native American Tribal Governments (Other than Federally Recognized); Non-domestic (non-U.S.) Entities (Foreign Organizations); Regional Organizations; Tribally Controlled Colleges and Universities (TCCUs) ; U.S. Territory or Possession.

How to apply

Applications go through the official government listing. Grants Radar links you straight to the source — applying is free.

View on Grants.gov Full announcement

Agency contact: National Institutes of Health · [email protected] · 301-402-2541

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