Archived

Centers for Precision Disease Modeling (U54) (Clinical Trials Not Allowed)

Federal funding opportunity PAR-24-305 from National Institutes of Health (Department of Health and Human Services).

Posted: October 4, 2024
Closed: December 15, 2024
Cost sharing: No
Instrument: Cooperative Agreement
Assistance listing: 93.351
Category: Health
Archives: January 20, 2025

Program funding history

Awards made under Assistance Listing 93.351 across FY2025–FY2027, from public federal spending records.

FY2025 obligated: $281.4M
FY2026 obligated: $276.6M
FY2027 (to date) obligated: $0
Awards in window: 894

Top recipients: University of California, Davis, Oregon Health & Science University, University of Washington, Emory University, The Administrators of Tulane Educational Fund

Source: USAspending.gov · refreshed October 2026 · Program page: awards, recipients and the opportunities under this listing →

This opportunity is archived. Applications are no longer accepted. Similar grants are listed below, and the free Tuesday digest carries the next ones like it.

Synopsis

This Notice of Funding Opportunity (NOFO) invites U54 cooperative agreement applications for the support and advancement of the Centers for Precision Disease Modeling. The goal of the Centers is to support collaborative research projects that bridge current personalized medicine efforts in human subjects with advances in animal genomics and genetic manipulation technologies, including the creation of interspecies somatic hybrids. By functionally linking these areas of research, the Centers aim to enhance the predictive value of preclinical studies through the use of precision animal models. Each Center will develop a process by which the research community can nominate unique human genomic variants for cost effective high-throughput testing in an animal model pipeline. After validation of the expected gene editing, the Centers will support assays to conduct comprehensive functional and phenotyping analyses to evaluate disease-causing variants. A key mission of the Centers is the creation and distribution of precision animal model resources and related services to the biomedical community. Therefore, Centers will establish pipelines for preclinical scientific discovery, disease modeling, and development of interventions based on innovative animal models. While the Centers will focus on a limited number of targeted projects, they are expected to develop and maintain multifaceted research activities that can be adjusted to accommodate a wide range of diseases.

Who can apply

City or township governments
State governments
Others (see text field entitled "Additional Information on Eligibility" for clarification)
Native American tribal organizations (other than Federally recognized tribal governments)
Private institutions of higher education
Small businesses
Special district governments
Native American tribal governments (Federally recognized)
Public housing authorities/Indian housing authorities
County governments
Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education
For profit organizations other than small businesses
Public and State controlled institutions of higher education
Independent school districts
Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education

Other Eligible Applicants include the following: Alaska Native and Native Hawaiian Serving Institutions; Asian American Native American Pacific Islander Serving Institutions (AANAPISISs); Eligible Agencies of the Federal Government; Faith-based or Community-based Organizations; Hispanic-serving Institutions; Historically Black Colleges and Universities (HBCUs); Indian/Native American Tribal Governments (Other than Federally Recognized); Non-domestic (non-U.S.) Entities (Foreign Organizations); Regional Organizations; Tribally Controlled Colleges and Universities (TCCUs) ; U.S. Territory or Possession; Non-domestic (non-U.S.) Entities (Foreign Organization) are not eligible to apply. Non-domestic (non-U.S.) components of U.S. Organizations are not eligible to apply. Foreign components, as defined in the NIH Grants Policy Statement, are not allowed.

The official record

Grants.gov published the official terms and dates of this opportunity; this page keeps them as they were listed.

View on Grants.gov Full announcement

Agency contact: National Institutes of Health · [email protected] · 301-402-2541

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