Validation Center for Precision Medicine with AI: Integrating Imaging with Multimodal Data (PRIMED-AI) (U54 Clinical Trials Not Allowed)

Federal funding opportunity RFA-RM-27-014 from National Institutes of Health (Department of Health and Human Services).

Apply on Grants.gov →Application closes October 2, 2026

Posted: June 30, 2026
Closes: October 2, 2026
Award ceiling: $2,000,000
Program funding: $2,700,000
Expected awards: 1
Cost sharing: No
Instrument: Cooperative Agreement
Assistance listing: 93.310
Category: Health
Archives: December 1, 2026

Program funding history

Awards made under Assistance Listing 93.310 across FY2024–FY2026, from public federal spending records.

FY2024 obligated: $1.2B
FY2025 obligated: $1B
FY2026 (to date) obligated: $314.8M
Awards in window: 4,776

Top recipients: Washington University, the, The Leland Stanford Junior University, The Johns Hopkins University, Yale Univ, New York University

Source: USAspending.gov · refreshed July 2026

Synopsis

The overarching goal of this notice of funding opportunity (NOFO) and its companion opportunities is to establish the Precision Medicine with AI: Integrating Imaging with Multimodal Data (PRIMED-AI) Program to support development of innovative, reliable, cost-effective, and sustainable multimodal AI-based clinical decision support (CDS) tools. PRIMED-AI CDS tools are based on the integration of clinical imaging with other types of multimodal health data to enhance care for patients with a wide range of health conditions. The PRIMED-AI Program seeks to catalyze the adoption of AI-based CDS tools into clinical workflows to enable novel personalized medicine strategies that address significant health challenges. The purpose of this NOFO is to solicit applications for the creation of a Validation Center to serve as a dedicated hub for the comprehensive evaluation and characterization of AI-enabled, image-based, multimodal CDS tools developed by the PRIMED-AI Consortium, to ensure these tools are reliable, reproducible, and generalizable. The Validation Center will focus on verification, validation, interoperability, and uncertainty quantification to comprehensively characterize performance of the CDS tools developed by the program. The core functions of the Validation Center will involve the systematic validation of PRIMED-AI Consortium deliverables, including those emerging from award recipients under the Playbook, Data-to-Model Academic-Industrial Partnerships, and Model-to-Clinic NOFOs.

Who can apply

Private institutions of higher education
Independent school districts
Small businesses
Native American tribal organizations (other than Federally recognized tribal governments)
City or township governments
Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education
Native American tribal governments (Federally recognized)
Others (see text field entitled "Additional Information on Eligibility" for clarification)
Special district governments
Public housing authorities/Indian housing authorities
For profit organizations other than small businesses
Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education
State governments
County governments
Public and State controlled institutions of higher education

Refer to Section III. Eligibility Information in the NOFO for additional information on eligibility.Foreign Organizations/International Collaborations:Non-domestic (non-U.S.) Entities (Foreign Organization) are not eligible to apply.Non-domestic (non-U.S.) components of U.S. Organizations are not eligible to apply.Foreign components, as defined in the NIH Grants Policy Statement, are not allowed.

How to apply

Applications go through the official government listing. Grants Radar links you straight to the source.

View on Grants.gov

Agency contact: National Institutes of Health · ODPRIMED-AI@od.nih.gov · 301-402-2541

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