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NIH Director’s Transformative Research Award for Individual and Group Science (R01 Clinical Trial Optional)

Federal funding opportunity RFA-RM-27-003 from National Institutes of Health (Department of Health and Human Services).

Apply on Grants.gov →Application closes September 3, 2026

Posted
June 29, 2026
Closes
September 3, 2026
Program funding
$8,000,000
Expected awards
7
Cost sharing
No
Instrument
Grant
Assistance listing
93.310
Category
Health
Archives
November 2, 2026

Program funding history

Awards made under Assistance Listing 93.310 across FY2024–FY2026, from public federal spending records.

FY2024 obligated
$1.2B
FY2025 obligated
$1B
FY2026 (to date) obligated
$314.8M
Awards in window
4,776

Top recipients: Washington University, the, The Leland Stanford Junior University, The Johns Hopkins University, Yale Univ, New York University

Source: USAspending.gov · refreshed July 2026

Synopsis

The NIH Director"s Transformative Research Award supports individual scientists or groups of scientists proposing bold, groundbreaking, exceptionally innovative, original, and/or unconventional research with the potential to create new scientific paradigms, establish entirely new and improved clinical approaches, or develop transformative technologies. Applications in any area within the biomedical sciences are welcome; topics may involve basic, translational, or clinical research. No preliminary data are required. Projects must clearly demonstrate, based on the strength of the logic, a compelling potential to produce a major impact in a broad area of relevance to the NIH. The NIH Director"s Transformative Research Award is a component of the High-Risk, High-Reward Research (HRHR) program of the NIH Common Fund.

Who can apply

Refer to Section III. Eligibility Information in the NOFO for additional information on eligibility.Foreign Organizations/International Collaborations:Non-domestic (non-U.S.) Entities (Foreign Organizations) are not eligible to apply.Non-domestic (non-U.S.) components of U.S. Organizations are not eligible to apply.Foreign components, as defined in the NIH Grants Policy Statement, are allowed.

How to apply

Applications go through the official government listing. Grants Radar links you straight to the source.

View on Grants.gov

Agency contact: National Institutes of Health · Transformative_Awards@mail.nih.gov · 301-402-2541

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