Closed

NIH Director’s Transformative Research Award for Individual and Group Science (R01 Clinical Trial Optional)

Federal funding opportunity RFA-RM-27-003 from National Institutes of Health (Department of Health and Human Services).

Posted: June 29, 2026
Closed: September 3, 2026
Program funding: $8,000,000
Expected awards: 7
Cost sharing: No
Instrument: Grant
Assistance listing: 93.310
Category: Health
Archives: November 2, 2026

Program funding history

Awards made under Assistance Listing 93.310 across FY2025–FY2027, from public federal spending records.

FY2025 obligated: $1B
FY2026 obligated: $993.8M
FY2027 (to date) obligated: $0
Awards in window: 4,544

Top recipients: Washington University, the, The Leland Stanford Junior University, The Children's Hospital of Philadelphia, The Broad Institute, Inc, New York University

Source: USAspending.gov · refreshed October 2026 · Program page: awards, recipients and the opportunities under this listing →

This opportunity is closed. Applications are no longer accepted. Similar grants are listed below, and the free Tuesday digest carries the next ones like it.

Synopsis

The NIH Director’s Transformative Research Award supports individual scientists or groups of scientists proposing bold, groundbreaking, exceptionally innovative, original, and/or unconventional research with the potential to create new scientific paradigms, establish entirely new and improved clinical approaches, or develop transformative technologies. Applications in any area within the biomedical sciences are welcome; topics may involve basic, translational, or clinical research. No preliminary data are required. Projects must clearly demonstrate, based on the strength of the logic, a compelling potential to produce a major impact in a broad area of relevance to the NIH. The NIH Director’s Transformative Research Award is a component of the High-Risk, High-Reward Research (HRHR) program of the NIH Common Fund.

Who can apply

Others (see text field entitled "Additional Information on Eligibility" for clarification)
Independent school districts
Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education
Public housing authorities/Indian housing authorities
Small businesses
Native American tribal organizations (other than Federally recognized tribal governments)
Special district governments
City or township governments
Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education
State governments
Native American tribal governments (Federally recognized)
For profit organizations other than small businesses
Public and State controlled institutions of higher education
County governments
Private institutions of higher education

Refer to Section III. Eligibility Information in the NOFO for additional information on eligibility. Foreign Organizations/International Collaborations: Non-domestic (non-U.S.) Entities (Foreign Organizations) are not eligible to apply. Non-domestic (non-U.S.) components of U.S. Organizations are not eligible to apply. Foreign components, as defined in the NIH Grants Policy Statement, are allowed.

The official record

Grants.gov published the official terms and dates of this opportunity; this page keeps them as they were listed.

View on Grants.gov

Agency contact: National Institutes of Health · [email protected] · 301-402-2541

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